Evidence map›Paper›PMID 39519142›Full record

ReviewInternational journal of molecular sciences2024

Recent Advances in Artificial Intelligence to Improve Immunotherapy and the Use of Digital Twins to Identify Prognosis of Patients with Solid Tumors.

Laura D'Orsi, Biagio Capasso, Giuseppe Lamacchia, Paolo Pizzichini, Sergio Ferranti, Andrea Liverani, Costantino Fontana, Simona Panunzi, Andrea De Gaetano, Elena Lo Presti

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura D'OrsiNational Research Council of Italy, Institute for Systems Analysis and Computer Science "A. Ruberti", BioMatLab, Via dei Taurini, 19, 00185 Rome, RM, Italy.
Biagio CapassoDepartment of General Surgery, Policlinico Militare di Roma "Celio", Piazza Celimontana, 50, 00184 Rome, RM, Italy.
Giuseppe LamacchiaGeneral Surgery Unit, Regina Apostolorum Hospital, Via S. Francesco d'Assisi, 50, 00041 Albano Laziale, RM, Italy.
Paolo PizzichiniDepartment of Intensive Care Unit, Policlinico Militare di Roma "Celio", Piazza Celimontana, 50, 00184 Rome, RM, Italy.ORCID 0009-0002-6477-7057
Sergio FerrantiDepartment of General Surgery, Policlinico Militare di Roma "Celio", Piazza Celimontana, 50, 00184 Rome, RM, Italy.
Andrea LiveraniGeneral Surgery Unit, Regina Apostolorum Hospital, Via S. Francesco d'Assisi, 50, 00041 Albano Laziale, RM, Italy.
Costantino FontanaDepartment of Intensive Care Unit, Policlinico Militare di Roma "Celio", Piazza Celimontana, 50, 00184 Rome, RM, Italy.
Simona PanunziNational Research Council of Italy, Institute for Systems Analysis and Computer Science "A. Ruberti", BioMatLab, Via dei Taurini, 19, 00185 Rome, RM, Italy.ORCID 0000-0003-0956-8578
Andrea De GaetanoNational Research Council of Italy, Institute for Systems Analysis and Computer Science "A. Ruberti", BioMatLab, Via dei Taurini, 19, 00185 Rome, RM, Italy.
Elena Lo PrestiNational Research Council of Italy, Institute for Biomedical Research and Innovation (CNR-IRIB), Via Ugo La Malfa, 153, 90146 Palermo, PA, Italy.ORCID 0000-0001-5401-4545

Funding

PNC-PNRR 3D4H project PNC0000001
6 · The paper itself

Abstract

To date, the public health system has been impacted by the increasing costs of many diagnostic and therapeutic pathways due to limited resources. At the same time, we are constantly seeking to improve these paths through approaches aimed at personalized medicine. To achieve the required levels of diagnostic and therapeutic precision, it is necessary to integrate data from different sources and simulation platforms. Today, artificial intelligence (AI), machine learning (ML), and predictive computer models are more efficient at guiding decisions regarding better therapies and medical procedures. The evolution of these multiparametric and multimodal systems has led to the creation of digital twins (DTs). The goal of our review is to summarize AI applications in discovering new immunotherapies and developing predictive models for more precise immunotherapeutic decision-making. The findings from this literature review highlight that DTs, particularly predictive mathematical models, will be pivotal in advancing healthcare outcomes. Over time, DTs will indeed bring the benefits of diagnostic precision and personalized treatment to a broader spectrum of patients.

Indexed as

Artificial IntelligenceImmunotherapyNeoplasmsPrecision MedicineHumansMachine LearningPrognosisartificial intelligencedigital twinsimmune checkpoint inhibitorimmunotherapymachine learning

Identifiers

PMID39519142
PMCPMC11546512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.