Evidence map›Paper›PMID 39519136›Full record

ArticleInternational journal of molecular sciences2024

The Role of Acid-Sensing Ion Channel 1A (ASIC1A) in the Behavioral and Synaptic Effects of Oxycodone and Other Opioids.

Margaret J Fuller, Noah R R Andrys, Subhash C Gupta, Ali Ghobbeh, Collin J Kreple, Rong Fan, Rebecca J Taugher-Hebl, Jason J Radley, Ryan T Lalumiere, John A Wemmie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Acetazolamide inhibition of carbonic anhydrase 4 reverses opioid-induced synaptic rearrangements in nucleus accumbens and reduces drug-seeking behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Margaret J FullerDepartment of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-6050-0646
Noah R R AndrysDepartment of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.
Subhash C GuptaDepartment of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.
Ali GhobbehDepartment of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.
Collin J KrepleDepartment of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA.
Rong FanDepartment of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.
Rebecca J Taugher-HeblDepartment of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-6710-984X
Jason J RadleyDepartment of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-5563-6637
Ryan T LalumiereDepartment of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, USA.
John A WemmieDepartment of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.

Funding

Medical Scientist Training ProgramT32GM139776 · NIGMS · UNIVERSITY OF IOWA · PI Gordon F Buchanan · 2021 to 2026
$6.4M
Novel mechanisms for correcting opioid-induced synaptic abnormalitiesR01DA052953 · NIDA · UNIVERSITY OF IOWA · PI WEMMIE, JOHN A · 2021 to 2025
$2.3M
Modulation of Synaptic and Behavioral Measures of Addiction by Acid-sensing Ion ChannelsR01DA037216 · NIDA · UNIVERSITY OF IOWA · PI LALUMIERE, RYAN T, WEMMIE, JOHN A · 2014 to 2018
$1.8M
BLRD VA I01 BX004440National Institute of Drug Abuse 5R01DA037216National Institute of Drug Abuse R01DA052953NIDA NIH HHS R01 DA037216NIDA NIH HHS R01 DA052953NIGMS NIH HHS 3T32GM139776NIGMS NIH HHS T32 GM139776VA IO1BX004440
6 · The paper itself

Abstract

Opioid-seeking behaviors depend on glutamatergic plasticity in the nucleus accumbens core (NAcc). Here we investigated whether the behavioral and synaptic effects of opioids are influenced by acid-sensing ion channel 1A (ASIC1A). We tested the effects of ASIC1A on responses to several opioids and found that

Indexed as

Acid Sensing Ion ChannelsAnalgesics, OpioidMice, KnockoutNucleus AccumbensOxycodoneAnimalsBehavior, AnimalDendritic SpinesMaleMiceMice, Inbred C57BLReceptors, AMPAReceptors, N-Methyl-D-AspartateSubstance Withdrawal SyndromeSynapsesAcid Sensing Ion ChannelsAnalgesics, OpioidASIC1 protein, mouseOxycodoneReceptors, AMPAReceptors, N-Methyl-D-AspartateAMPAR/NMDARASICASIC1Adendritic spinenucleus accumbensopioidopioid use disorderoxycodonesubstance use disorderwithdrawal

Identifiers

PMID39519136
PMCPMC11545886

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.