Evidence map›Paper›PMID 39519118›Full record

ArticleInternational journal of molecular sciences2024

Evaluation of Targeted Alpha Therapy Using [

Kaori Abe, Tadashi Watabe, Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Yuichiro Kadonaga, Sadahiro Naka, Kazuhiro Ooe, Atsushi Toyoshima, Frederik Giesel, Takeshi Usui and 9 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Comparison between [EJNMMI research · 2026
    Article
  5. Review
  6. A newEJNMMI radiopharmacy and chemistry · 2026
    Article
  7. Future of radiotheranostics.BMJ oncology · 2026
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kaori AbeDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.ORCID 0009-0000-8849-5711
Tadashi WatabeDepartment of Radiology, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.ORCID 0000-0001-8658-2395
Kazuko Kaneda-NakashimaInstitute for Radiation Sciences, Osaka University, Suita 565-0871, Japan.ORCID 0000-0001-6657-5059
Yoshifumi ShirakamiInstitute for Radiation Sciences, Osaka University, Suita 565-0871, Japan.ORCID 0000-0003-2352-9057
Yuichiro KadonagaInstitute for Radiation Sciences, Osaka University, Suita 565-0871, Japan.
Sadahiro NakaDepartment of Pharmacy, Osaka University Hospital, Suita 565-0871, Japan.
Kazuhiro OoeInstitute for Radiation Sciences, Osaka University, Suita 565-0871, Japan.ORCID 0000-0002-8560-027X
Atsushi ToyoshimaInstitute for Radiation Sciences, Osaka University, Suita 565-0871, Japan.
Frederik GieselInstitute for Radiation Sciences, Osaka University, Suita 565-0871, Japan.
Takeshi UsuiDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.ORCID 0009-0009-0510-6756
Nanae MasunagaDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.ORCID 0000-0002-6164-5107
Chieko MishimaDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Masami TsukabeDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.ORCID 0009-0009-3284-0833
Tetsuhiro YoshinamiDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Yoshiaki SotaDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.ORCID 0000-0001-5963-652X
Tomohiro MiyakeDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Tomonori TaneiDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Masafumi ShimodaDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Kenzo ShimazuDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.

Funding

the Japanese Science and Technology Agency (JST) and KAKENHI Grant-in-Aid for Scientific Research (C) (grant number: 22K07231) and (B) (grant number: 24K02404)
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) presents limited therapeutic options and is associated with poor prognosis. Early detection and the development of novel therapeutic agents are therefore imperative. Fibroblast activation protein (FAP) is a membrane protein expressed on cancer-associated fibroblasts (CAFs) that plays an essential role in TNBC proliferation, migration, and invasion. Consequently, it is hypothesized that the Astatine (

Indexed as

Triple Negative Breast NeoplasmsXenograft Model Antitumor AssaysAlpha ParticlesAnimalsAstatineCell Line, TumorEndopeptidasesFemaleFibroblast Activation Protein AlphaGelatinasesHumansMembrane ProteinsMiceMice, Inbred BALB CMice, NudePositron-Emission TomographyAstatineEndopeptidasesFibroblast Activation Protein AlphaGelatinasesMembrane ProteinsRadiopharmaceuticalsSerine Endopeptidases[211At]FAPI1Astatine (211At)CAFFAPFAPI-PETtheranosticstriple-negative breast cancerα-emitting nuclides

Identifiers

PMID39519118
PMCPMC11547022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.