Evidence map›Paper›PMID 39519108›Full record

ArticleInternational journal of molecular sciences2024

GM1 Oligosaccharide Ameliorates Rett Syndrome Phenotypes In Vitro and In Vivo via Trk Receptor Activation.

Maria Fazzari, Giulia Lunghi, Emma Veronica Carsana, Manuela Valsecchi, Eleonora Spiombi, Martina Breccia, Silvia Rosanna Casati, Silvia Pedretti, Nico Mitro, Laura Mauri and 5 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Toward an NGF-based therapy for Rett syndrome.Frontiers in neuroscience · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maria FazzariDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0001-7034-9820
Giulia LunghiDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0002-3099-3395
Emma Veronica CarsanaDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0003-1486-550X
Manuela ValsecchiDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, 20054 Segrate, Italy.
Eleonora SpiombiDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, 20054 Segrate, Italy.
Martina BrecciaDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, 20054 Segrate, Italy.
Silvia Rosanna CasatiDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0002-4393-7691
Silvia PedrettiDepartment of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Università degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0001-6404-6321
Nico MitroDepartment of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Università degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0002-5000-3619
Laura MauriDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0002-4194-4804
Maria Grazia CiampaDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, 20054 Segrate, Italy.
Sandro SonninoDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0001-8180-5908
Nicoletta LandsbergerDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0003-0820-3155
Angelisa FrascaDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0002-0963-9789
Elena ChiricozziDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0001-7431-9207

Funding

Fondation Jerome Lejeune GRT#2039Italian Ministry of Health 5xmilleItalian Ministry of Health Ricerca CorrenteMinistry of University and Research (MUR) Progetto Eccellenza (2023-2027) to the Department of Pharmacological and Biomolecular Scienc-es "Rodolfo Paoletti", Università degli Studi di Milano
6 · The paper itself

Abstract

Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily caused by mutations in the methyl-CpG binding protein 2 (

Indexed as

G(M1) GangliosideMethyl-CpG-Binding Protein 2NeuronsRett SyndromeAnimalsDisease Models, AnimalMiceMice, KnockoutMitochondriaOligosaccharidesOxidative StressPhenotypeG(M1) GangliosideMethyl-CpG-Binding Protein 2OligosaccharidesGM1 gangliosideGM1 oligosaccharidemitochondrial oxidative stressneurotrophins’ signalingRett syndrome

Identifiers

PMID39519108
PMCPMC11547101

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.