Evidence map›Paper›PMID 39519103›Full record

ArticleInternational journal of molecular sciences2024

Platelet Glycoprotein Ibα Cytoplasmic Tail Exacerbates Thrombosis During Bacterial Sepsis.

Yue Xia, Chenglin Sun, Kangxi Zhou, Jie Shen, Jiaojiao Li, Qiuxia Huang, Jiahao Du, Sai Zhang, Kang Sun, Renping Hu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Low NAPR as a Novel Indicator for PredictingClinical interventions in aging · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yue XiaJiangsu Institute of Hematology, Cyrus Tang Medical Institute, Suzhou Medical College of Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases, Suzhou 215123, China.
Chenglin SunJiangsu Institute of Hematology, Cyrus Tang Medical Institute, Suzhou Medical College of Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases, Suzhou 215123, China.
Kangxi ZhouJiangsu Institute of Hematology, Cyrus Tang Medical Institute, Suzhou Medical College of Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases, Suzhou 215123, China.
Jie ShenJiangsu Institute of Hematology, Cyrus Tang Medical Institute, Suzhou Medical College of Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases, Suzhou 215123, China.
Jiaojiao LiJiangsu Institute of Hematology, Cyrus Tang Medical Institute, Suzhou Medical College of Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases, Suzhou 215123, China.
Qiuxia HuangJiangsu Institute of Hematology, Cyrus Tang Medical Institute, Suzhou Medical College of Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases, Suzhou 215123, China.
Jiahao DuJiangsu Institute of Hematology, Cyrus Tang Medical Institute, Suzhou Medical College of Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases, Suzhou 215123, China.
Sai ZhangJiangsu Institute of Hematology, Cyrus Tang Medical Institute, Suzhou Medical College of Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases, Suzhou 215123, China.
Kang SunJiangsu Institute of Hematology, Cyrus Tang Medical Institute, Suzhou Medical College of Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases, Suzhou 215123, China.
Renping HuJiangsu Institute of Hematology, Cyrus Tang Medical Institute, Suzhou Medical College of Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases, Suzhou 215123, China.
Rong YanJiangsu Institute of Hematology, Cyrus Tang Medical Institute, Suzhou Medical College of Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases, Suzhou 215123, China.
Kesheng DaiJiangsu Institute of Hematology, Cyrus Tang Medical Institute, Suzhou Medical College of Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases, Suzhou 215123, China.

Funding

the Key Program of the National Natural Science Foundation of China 81130008
6 · The paper itself

Abstract

Septic patients, coupling severe disseminated intravascular coagulation (DIC) and thrombocytopenia, have poor prognoses and higher mortality. The platelet glycoprotein Ibα (GPIbα) is involved in thrombosis, hemostasis, and inflammation response. However, it remains unclear whether the GPIbα cytoplasmic tail regulates sepsis-mediated platelet activation and inflammation, especially in Staphylococcus aureus (

Indexed as

BacteremiaPlatelet ActivationPlatelet Glycoprotein GPIb-IX ComplexProtein Kinase CThrombosisAnimalsFemaleHealthy VolunteersHumansIndolesInterleukin-6MaleMaleimidesMiceMice, Inbred C57BLProtein Kinase Inhibitors2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimideglycocalicinIndolesInterleukin-6MaleimidesPlatelet Glycoprotein GPIb-IX ComplexProtein Kinase CProtein Kinase InhibitorsTumor Necrosis Factor-alphabacterial infectionGPIbαinflammationPKCplatelet activation

Identifiers

PMID39519103
PMCPMC11546206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.