Synthetic Flavonoid 3,7-Dihydroxy-Isoflav-3-Ene (DHIF) Reduces In-Stent Restenosis in an Atherosclerotic Watanabe Heritable Hyperlipidemic Rabbit Stent Model.

Jarkko P Hytönen, Olli Leppänen, Jouni Taavitsainen, Seppo Ylä-Herttuala

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Editorial for the Special Issue Titled "Molecular Pharmacology and Interventions in Cardiovascular Disease".International journal of molecular sciences · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jarkko P HytönenA.I. Virtanen Institute, University of Eastern Finland, 70210 Kuopio, Finland.ORCID 0000-0001-9120-7645

Olli LeppänenA.I. Virtanen Institute, University of Eastern Finland, 70210 Kuopio, Finland.

Jouni TaavitsainenA.I. Virtanen Institute, University of Eastern Finland, 70210 Kuopio, Finland.

Seppo Ylä-HerttualaA.I. Virtanen Institute, University of Eastern Finland, 70210 Kuopio, Finland.ORCID 0000-0001-7593-2708

Funding

Research Council of Finland 37210

6 · The paper itself

Abstract

Inflammation is a major component of the pathogenesis of atherosclerosis and the formation of in-stent restenosis (ISR). A novel flavonoid, DHIF, attenuates reactive oxygen species and nf-κB signaling and has potential to limit ISR via antioxidant action. While current drug eluting stents (DESs) perform well in clinical practice, new therapies to prevent ISR without dependance on cytotoxic drugs are warranted. Our objective was to test whether DHIF reduces ISR in a hyperlipidemic rabbit aorta model of ISR via attenuated inflammatory responses. WHHL rabbit aortas (

Indexed as

Disease Models, AnimalAnimalsAortaAtherosclerosisDrug-Eluting StentsFlavonoidsHyperlipidemiasMaleRabbitsStentsFlavonoidsantioxidant: redoxNF-kappaBphytochemicalphytoestrogenrabbit modelrestenosissuperoxidevessel injury

Identifiers

PMID39519083

DOI10.3390/ijms252111530

PMCPMC11546789

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.