Evidence map›Paper›PMID 39519058›Full record

ArticleInternational journal of molecular sciences2024

A Comparison of Molecular Techniques for Improving the Methodology in the Laboratory of Pharmacogenetics.

María Celsa Peña-Martín, Elena Marcos-Vadillo, Belén García-Berrocal, David Hansoe Heredero-Jung, María Jesús García-Salgado, Sandra Milagros Lorenzo-Hernández, Romain Larrue, Marie Lenski, Guillaume Drevin, Catalina Sanz and 1 more

Abstract readComparative Study
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Advances in laboratory medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

María Celsa Peña-MartínDepartment of Clinical Biochemistry, University Hospital of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-3670-9228
Elena Marcos-VadilloDepartment of Clinical Biochemistry, University Hospital of Salamanca, 37007 Salamanca, Spain.
Belén García-BerrocalDepartment of Clinical Biochemistry, University Hospital of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-1397-9508
David Hansoe Heredero-JungDepartment of Clinical Biochemistry, University Hospital of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-6631-9319
María Jesús García-SalgadoDepartment of Clinical Biochemistry, University Hospital of Salamanca, 37007 Salamanca, Spain.
Sandra Milagros Lorenzo-HernándezDepartment of Clinical Biochemistry, University Hospital of Salamanca, 37007 Salamanca, Spain.ORCID 0009-0004-1685-4315
Romain LarrueCNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, University of Lille, F-59000 Lille, France.
Marie LenskiCHU Lille, Institut Pasteur de Lille, ULR 4483, IMPECS-IMPact of the Chemical Environment on Health, University of Lille, F-59000 Lille, France.ORCID 0000-0001-8301-857X
Guillaume DrevinPharmacology-Toxicology and Pharmacovigilance Department, Angers University Hospital, F-49100 Angers, France.
Catalina SanzInstitute for Biomedical Research of Salamanca, 37007 Salamanca, Spain.
María Isidoro-GarcíaDepartment of Clinical Biochemistry, University Hospital of Salamanca, 37007 Salamanca, Spain.

Funding

ISCIII (CIBERCV) and European Regional Development Fund (ERDF) "A way to make Europe". project IMP/00009
6 · The paper itself

Abstract

One of the most critical goals in healthcare is safe and effective drug therapy, which is directly related to an individual's response to treatment. Precision medicine can improve drug safety in many scenarios, including polypharmacy, and it requires the development of new genetic characterization methods. In this report, we use real-time PCR, microarray techniques, and mass spectrometry (MALDI-TOF), which allows us to compare them and identify the potential benefits of technological improvements, leading to better quality medical care. These comparative studies, as part of our pharmacogenetic Five-Step Precision Medicine (5SPM) approach, reveal the superiority of mass spectrometry over the other methods analyzed and highlight the importance of updating the laboratory's pharmacogenetic methodology to identify new variants with clinical impact.

Indexed as

PharmacogeneticsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationHumansPrecision MedicineReal-Time Polymerase Chain Reactionmass spectrometrymicroarraypharmacogeneticspolypharmacyprecision medicinereal-time PCR

Identifiers

PMID39519058
PMCPMC11546559

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.