Evidence map›Paper›PMID 39519040›Full record

ArticleInternational journal of molecular sciences2024

Gender-Specific DNA Methylation Profiles Associated with Adult Weight in Hezuo Pigs.

Rui Jia, Xiaoyu Huang, Jiaojiao Yang, Longlong Wang, Jie Li, Yao Li, Shuangbao Gun, Zunqiang Yan, Pengfei Wang, Qiaoli Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rui JiaCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Xiaoyu HuangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Jiaojiao YangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Longlong WangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Jie LiCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Yao LiCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Shuangbao GunCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Zunqiang YanCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.ORCID 0000-0001-8701-0647
Pengfei WangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Qiaoli YangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.

Funding

Gun Shuangbao U22A20507Yang Qiaoli GAU-XKTD-2022-25,2017RCZX-15
6 · The paper itself

Abstract

The Hezuo pig, an important native Tibetan breed in China, exhibits differences in adult body weight, with females typically heavier than males. The underlying mechanisms for this disparity remain unclear. DNA methylation changes are known to influence animal growth and development and regulate Hezuo pig growth by altering gene expression related to these processes, thus differentially affecting adult body weight between genders. This study conducted DNA methylation analysis and expression profiling using pituitary tissues from male and female Hezuo pigs at 3 and 8 months old (M3M, M3F, M8M, and M8F). In total 346, 795, 371, and 839 differentially methylated genes (DMGs) were identified in the M3M vs. M3F, M3F vs. M8F, M3M vs. M8M, and M8M vs. M8F groups, respectively. The comparative analysis of differentially methylated regions (DMRs) genes and DEGs (differentially expressed regions) revealed that key genes involved in growth, hormone secretion, and the hypothalamic-pituitary-gonadal axis are primarily enriched in signaling pathways such as PI3K-Akt, Hippo, and adrenergic. Further analysis combining methylation and transcriptomics identified five candidate methylated genes (

Indexed as

Body WeightDNA MethylationAnimalsFemaleGene Expression ProfilingMaleSex CharacteristicsSex FactorsSwineTranscriptomeDNA methylationHezuo pigsweightwhole genome bisulfite sequencing

Identifiers

PMID39519040
PMCPMC11547036

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.