Evidence map›Paper›PMID 39519034›Full record

ArticleInternational journal of molecular sciences2024

Enhancing Proton Radiosensitivity of Chondrosarcoma Using Nanoparticle-Based Drug Delivery Approaches: A Comparative Study of High- and Low-Energy Protons.

Mihaela Tudor, Roxana Cristina Popescu, Ionela N Irimescu, Ann Rzyanina, Nicolae Tarba, Anca Dinischiotu, Liviu Craciun, Tiberiu Relu Esanu, Eugeniu Vasile, Andrei Theodor Hotnog and 4 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mihaela TudorDepartment of Life and Environmental Physics, Horia Hulubei National Institute of Physics and Nuclear Engineering, Reactorului 30, P.O. Box MG-6, 077125 Magurele, Romania.
Roxana Cristina PopescuDepartment of Life and Environmental Physics, Horia Hulubei National Institute of Physics and Nuclear Engineering, Reactorului 30, P.O. Box MG-6, 077125 Magurele, Romania.
Ionela N IrimescuApplied Sciences Doctoral School, National University for Science and Technology Politehnica of Bucharest, 060042 Bucharest, Romania.
Ann RzyaninaLaboratory of Nuclear Problems, Joint Institute for Nuclear Research, 6 Joliot-Curie Street, 141980 Dubna, Moscow Region, Russia.
Nicolae TarbaDoctoral School of Computer Sciences, National University for Science and Technology Politehnica of Bucharest, 060042 Bucharest, Romania.ORCID 0000-0002-7769-8289
Anca DinischiotuFaculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania.
Liviu CraciunRadiopharmaceutical Research Centre, Horia Hulubei National Institute of Physics and Nuclear Engineering, 077125 Magurele, Romania.ORCID 0009-0005-9006-217X
Tiberiu Relu EsanuRadiopharmaceutical Research Centre, Horia Hulubei National Institute of Physics and Nuclear Engineering, 077125 Magurele, Romania.
Eugeniu VasileFaculty of Applied Physics, National University for Science and Technology Politehnica of Bucharest, 060042 Bucharest, Romania.
Andrei Theodor HotnogApplied Nuclear Physics Department, Horia Hulubei National Institute of Physics and Nuclear Engineering, Reactorului 30, P.O. Box MG-6, 077125 Magurele, Romania.
Mihai RaduDepartment of Life and Environmental Physics, Horia Hulubei National Institute of Physics and Nuclear Engineering, Reactorului 30, P.O. Box MG-6, 077125 Magurele, Romania.ORCID 0000-0003-1128-8153
Gennady MytsinLaboratory of Nuclear Problems, Joint Institute for Nuclear Research, 6 Joliot-Curie Street, 141980 Dubna, Moscow Region, Russia.
Mona MihailescuHolographic Imaging and Processing Laboratory, Physics Department, National University for Science and Technology Politehnica of Bucharest, 060042 Bucharest, Romania.ORCID 0000-0003-0337-8757
Diana Iulia SavuDepartment of Life and Environmental Physics, Horia Hulubei National Institute of Physics and Nuclear Engineering, Reactorului 30, P.O. Box MG-6, 077125 Magurele, Romania.ORCID 0000-0002-0145-5176

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To overcome chondrosarcoma's (CHS) high chemo- and radioresistance, we used polyethylene glycol-encapsulated iron oxide nanoparticles (IONPs) for the controlled delivery of the chemotherapeutic doxorubicin (IONP

Indexed as

Cell SurvivalChondrosarcomaDoxorubicinProtonsBone NeoplasmsCell Line, TumorDNA DamageDrug Delivery SystemsFerric CompoundsHumansLinear Energy TransferNanoparticlesPolyethylene GlycolsProton TherapyRadiation ToleranceDoxorubicinFerric Compoundsferric oxidePolyethylene GlycolsProtonschondrosarcomadoxorubicindrug deliveryhyperspectral imagingiron oxide nanoparticlesprotonsradiosensitization

Identifiers

PMID39519034
PMCPMC11546389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.