Evidence map›Paper›PMID 39519005›Full record

ArticleInternational journal of molecular sciences2024

Novel Expression of Apical Bile Acid Transport (ASBT) More Proximally Than Distal Ileum Contributing to Enhanced Intestinal Bile Acid Absorption in Obesity.

Shanmuga Sundaram, Arunkumar Jagadeesan, Raja Singh Paulraj, Uma Sundaram, Subha Arthur

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Emerging Roles of Bile Acids in Neuroinflammation.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shanmuga SundaramDepartment of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Huntington, WV 25701, USA.
Arunkumar JagadeesanDepartment of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Huntington, WV 25701, USA.ORCID 0000-0001-7665-595X
Raja Singh PaulrajDepartment of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Huntington, WV 25701, USA.ORCID 0000-0002-1487-5460
Uma SundaramDepartment of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Huntington, WV 25701, USA.ORCID 0000-0002-9322-6740
Subha ArthurDepartment of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Huntington, WV 25701, USA.

Funding

Regulation of Tight Junction Molecular Composition by Na/K-ATPaseP20GM121299 · NIGMS · MARSHALL UNIVERSITY · PI HAYNES, JENNIFER · 2018 to 2022
$10.6M
REGULATION OF INTESTINAL NA ABSORPTIONR01DK067420 · NIDDK · WEST VIRGINIA UNIVERSITY · PI SUNDARAM, UMA · 2004 to 2016
$3.2M
Regulation of amino acid absorption in the mammalian small intestineR01DK108054 · NIDDK · MARSHALL UNIVERSITY · PI SUNDARAM, UMA · 2016 to 2020
$2.4M
BLRD VA I01 BX003443National Institute of Health DK-108054National Institute of Health DK-67420National Institute of Health P20GM121299-01A1NIDDK NIH HHS R01 DK067420NIDDK NIH HHS R01 DK108054NIGMS NIH HHS P20 GM121299Veteran's Administration Merit Review BX003443-01
6 · The paper itself

Abstract

Dietary lipid absorption is facilitated by bile acids. In the Zucker rat (ZR) model of obesity, bile acid absorption, mediated by the apical sodium bile acid transporter (ASBT), was increased in villus cells from the distal ileum. However, whether ASBT may be de novo expressed more proximally in the small intestine during obesity to facilitate additional bile acid absorption is not known. For this, starting from the end of the ileum to the mid jejunum, caudal-orally, five intestinal segments of equal length (S1-S5) were separated from lean and obese ZRs (LZR and OZR). Intestinal mucosa obtained from these segments were used for total RNA extraction, RT-qPCR and

Indexed as

Bile Acids and SaltsIleumIntestinal AbsorptionObesityOrganic Anion Transporters, Sodium-DependentRats, ZuckerSymportersAnimalsIntestinal MucosaMaleRatsReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearBile Acids and SaltsOrganic Anion Transporters, Sodium-DependentReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and Nuclearsodium-bile acid cotransporterSymportersapical sodium bile acid transporterbile acidsfarnesoid X receptorintestinal physiologymetabolic disordersobesityobesity-related risk factors

Identifiers

PMID39519005
PMCPMC11547122

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.