Evidence map›Paper›PMID 39518995›Full record

ArticleInternational journal of molecular sciences2024

Investigating the Impact of the Parkinson's-Associated GBA1 E326K Mutation on β-Glucocerebrosidase Dimerization and Interactome Dynamics Through an In Silico Approach.

Davide Pietrafesa, Alessia Casamassa, Barbara Benassi, Massimo Santoro, Massimo Marano, Claudia Consales, Jessica Rosati, Caterina Arcangeli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. E326KJournal of Parkinson's disease · 2026
    Article
  3. Article
  4. Article
  5. A Common PD-RiskbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Davide PietrafesaDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy.ORCID 0009-0009-5154-6154
Alessia CasamassaCellular Reprogramming Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale dei Cappuccini 1, 71013 San Giovanni Rotondo, Italy.
Barbara BenassiDivision of Biotechnologies, Department for Sustainability, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Via Anguillarese 301, 00123 Rome, Italy.ORCID 0000-0002-6570-4434
Massimo SantoroDivision of Biotechnologies, Department for Sustainability, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Via Anguillarese 301, 00123 Rome, Italy.
Massimo MaranoUnit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Department of Medicine, University Campus Biomedico, Via Alvaro del Portillo 200, 00128 Rome, Italy.ORCID 0000-0001-9885-3666
Claudia ConsalesDivision of Biotechnologies, Department for Sustainability, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Via Anguillarese 301, 00123 Rome, Italy.ORCID 0000-0002-7805-4493
Jessica RosatiCellular Reprogramming Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale dei Cappuccini 1, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0002-4483-386X
Caterina ArcangeliDivision of Biotechnologies, Department for Sustainability, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Via Anguillarese 301, 00123 Rome, Italy.ORCID 0000-0002-5459-1024

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heterozygous mutations or genetic variants in the

Indexed as

alpha-SynucleinGlucosylceramidaseMolecular Dynamics SimulationParkinson DiseaseProtein MultimerizationHumansLysosomesMutationProtein BindingSaposinsalpha-SynucleinGBA protein, humanGlucosylceramidaseSaposinsGaucher diseaseGCase dimer structureLIMP-2molecular dynamics simulationpH effectSap Cα-Syn

Identifiers

PMID39518995
PMCPMC11870034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.