Evidence map›Paper›PMID 39518976›Full record

ArticleInternational journal of molecular sciences2024

Hyun Jin Bang, Hyun-Jeong Shim, Mi-Ra Park, Sumin Yoon, Kyung Hyun Yoo, Young-Kook Kim, Hyunju Lee, Jeong-Seok Nam, Jun-Eul Hwang, Woo-Kyun Bae and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hyun Jin BangDivision of Hematology and Oncology, Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun 58128, Republic of Korea.
Hyun-Jeong ShimDivision of Hematology and Oncology, Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun 58128, Republic of Korea.ORCID 0000-0001-7450-7822
Mi-Ra ParkDivision of Hematology and Oncology, Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun 58128, Republic of Korea.
Sumin YoonLaboratory of Biomedical Genomics, Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.ORCID 0009-0008-1638-8288
Kyung Hyun YooLaboratory of Biomedical Genomics, Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Young-Kook KimDepartment of Biochemistry, Chonnam National University Medical School, Hwasun 58128, Republic of Korea.
Hyunju LeeSchool of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.ORCID 0000-0003-2389-7183
Jeong-Seok NamSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.ORCID 0000-0001-9753-6095
Jun-Eul HwangDivision of Hematology and Oncology, Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun 58128, Republic of Korea.
Woo-Kyun BaeDivision of Hematology and Oncology, Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun 58128, Republic of Korea.ORCID 0000-0003-0267-1943
Ik-Joo ChungDivision of Hematology and Oncology, Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun 58128, Republic of Korea.
Eun-Gene SunDivision of Hematology and Oncology, Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun 58128, Republic of Korea.
Sang-Hee ChoDivision of Hematology and Oncology, Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun 58128, Republic of Korea.

Funding

Chonnam National University Hwasun Hospital 21003, 24003National Research Foundation of Korea 2020M3A9G3080281, 2021R1A2C1094854, 2020R1l1A3074402
6 · The paper itself

Abstract

The role of biomarkers in cancer treatment varies significantly depending on the cancer stage. Thus, in clinical practice, tailoring biomarkers to meet the specific needs and challenges of each cancer stage can increase the precision of treatment. Because they reflect underlying genetic alterations that influence cancer progression, copy number variation (CNV) biomarkers can play crucial prognostic roles. In our previous study, we identified potential survival-related genes for colorectal cancer (CRC) by analyzing CNV and gene expression data using a machine-learning approach. To further investigate the biological function of NRXN1, we assessed the use of RNA sequencing, phosphokinase assays, real-time quantitative PCR, and Western blot analysis. We found that

Indexed as

Biomarkers, TumorCalcium-Binding ProteinsColonic NeoplasmsDNA Copy Number VariationsEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticAgedCell Adhesion Molecules, NeuronalCell Line, TumorFemaleGlycogen Synthase Kinase 3 betaHumansMaleMiddle AgedNeural Cell Adhesion MoleculesPrognosisBiomarkers, TumorCalcium-Binding ProteinsCell Adhesion Molecules, NeuronalGlycogen Synthase Kinase 3 betaNeural Cell Adhesion MoleculesNRXN1 protein, humancolorectal cancer (CRC)epithelial–mesenchymal transitionmechanisms of inhibition

Identifiers

PMID39518976
PMCPMC11546699

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.