Evidence map›Paper›PMID 39518967›Full record

ArticleInternational journal of molecular sciences2024

2-Bromopalmitate-Induced Intestinal Flora Changes and Testicular Dysfunction in Mice.

Yuxuan Ma, Yining Chen, Long Li, Zifang Wu, Heran Cao, Chao Zhu, Qimin Liu, Yang Wang, Shaoxian Chen, Yuyan Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuxuan MaCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling 712100, China.
Yining ChenCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling 712100, China.
Long LiCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling 712100, China.
Zifang WuCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling 712100, China.
Heran CaoCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling 712100, China.
Chao ZhuCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling 712100, China.
Qimin LiuCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling 712100, China.
Yang WangCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling 712100, China.
Shaoxian ChenCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling 712100, China.
Yuyan LiuCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling 712100, China.
Wuzi DongCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling 712100, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

2-Bromopalmitate (2-BP) is a palmitoylation inhibitor that can prevent the binding of palmitic acid to proteins, thereby exhibiting significant effects in promoting inflammation and regulating the immune system. However, limited research has been conducted regarding the direct effects of 2-BP on the animal organism. Therefore, we probed mice injected with 2-BP for altered expression of inflammatory genes, with a focus on demonstrating changes in the intestinal flora as well as damage to the reproductive system. Our findings indicate that 2-BP can induce substantial inflammatory responses in visceral organs and cause testicular dysfunction. The key changes in the gut microbiota were characterized by an abundance of

Indexed as

Gastrointestinal MicrobiomePalmitatesTestisAnimalsInflammationMaleMiceTesticular Diseases2-bromopalmitatePalmitates2-bromopalmitateintestinal floratesticular dysfunction

Identifiers

PMID39518967
PMCPMC11547043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.