Evidence map›Paper›PMID 39518963›Full record

ArticleInternational journal of molecular sciences2024

Raman Spectroscopic Algorithms for Assessing Virulence in Oral Candidiasis: The Fight-or-Flight Response.

Giuseppe Pezzotti, Tetsuya Adachi, Hayata Imamura, Saki Ikegami, Ryo Kitahara, Toshiro Yamamoto, Narisato Kanamura, Wenliang Zhu, Ken-Ichi Ishibashi, Kazu Okuma and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Raman signatures ofFrontiers in microbiology · 2026
    Article
  3. Deciphering macrophage molecular responses toFrontiers in microbiology · 2026
    Article
  4. Review
  5. Raman Monitoring ofInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Giuseppe PezzottiCeramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, Kyoto 606-8585, Japan.
Tetsuya AdachiDepartment of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, 465 Kajii-cho, Kyoto 602-8566, Japan.ORCID 0000-0001-5224-7812
Hayata ImamuraCeramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, Kyoto 606-8585, Japan.
Saki IkegamiCeramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, Kyoto 606-8585, Japan.
Ryo KitaharaStructural Biology Laboratory, College of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Kusatsu 525-8577, Japan.ORCID 0000-0003-1815-3227
Toshiro YamamotoDepartment of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan.ORCID 0000-0001-9797-1556
Narisato KanamuraDepartment of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan.
Wenliang ZhuCeramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, Kyoto 606-8585, Japan.ORCID 0000-0001-7532-9714
Ken-Ichi IshibashiLaboratory of Host Defense and Responses, Faculty of Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Saitama, Sakado, Saitama 350-0288, Japan.
Kazu OkumaDepartment of Microbiology, Graduate School of Medicine, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 573-1010, Japan.ORCID 0009-0005-9719-0350
Osam MazdaDepartment of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, 465 Kajii-cho, Kyoto 602-8566, Japan.
Aya KomoriMedical Mycology, Graduate School of Medicine, Teikyo University, Itabashi-ku, Tokyo 173-8605, Japan.
Hitoshi KomatsuzawaDepartment of Bacteriology, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Koichi MakimuraMedical Mycology, Graduate School of Medicine, Teikyo University, Itabashi-ku, Tokyo 173-8605, Japan.ORCID 0000-0003-1645-3445

Funding

Japan Society for the Promotion of Science 22K10128, 23K09359, 23K09196
6 · The paper itself

Abstract

This study aimed to test the effectiveness of Raman spectroscopy in the characterization of the degrees of physiological stress and virulence in clinical swab samples collected from patients affected by oral candidiasis. Raman experiments were conducted on a series of eight isolates, both in an as-collected state and after biofilm purification followed by 3 days of culture. The outputs were matched to optical microscopy observations and the results of conventional chromogenic medium assays. A statistically significant series of ten Raman spectra were collected for each clinical sample, and their averages were examined and interpreted as multiomic snapshots for

Indexed as

AlgorithmsBiofilmsCandidiasis, OralSpectrum Analysis, RamanCandidaCandida albicansHumansVirulencebedside analysismorphogenic stateoral candidiasisRaman spectroscopyvirulence

Identifiers

PMID39518963
PMCPMC11545699

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.