Evidence map›Paper›PMID 39518932›Full record

ArticleInternational journal of molecular sciences2024

7-Ketocholesterol Effects on Osteogenic Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells.

Beatriz Araújo Oliveira, Débora Levy, Jessica Liliane Paz, Fabio Alessandro de Freitas, Cadiele Oliana Reichert, Alessandro Rodrigues, Sérgio Paulo Bydlowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Beatriz Araújo OliveiraLipids, Oxidation, and Cell Biology Team, Laboratory of Immunology (LIM19), Heart Institute (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, Brazil.
Débora LevyLipids, Oxidation, and Cell Biology Team, Laboratory of Immunology (LIM19), Heart Institute (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, Brazil.ORCID 0000-0001-7492-997X
Jessica Liliane PazLipids, Oxidation, and Cell Biology Team, Laboratory of Immunology (LIM19), Heart Institute (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, Brazil.
Fabio Alessandro de FreitasLipids, Oxidation, and Cell Biology Team, Laboratory of Immunology (LIM19), Heart Institute (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, Brazil.ORCID 0000-0001-5745-7843
Cadiele Oliana ReichertLipids, Oxidation, and Cell Biology Team, Laboratory of Immunology (LIM19), Heart Institute (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, Brazil.ORCID 0000-0002-4327-3928
Alessandro RodriguesDepartment of Earth and Exact Sciences, Universidade Federal de Sao Paulo, Diadema 09972-270, SP, Brazil.ORCID 0000-0002-0424-9765
Sérgio Paulo BydlowskiLipids, Oxidation, and Cell Biology Team, Laboratory of Immunology (LIM19), Heart Institute (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, Brazil.ORCID 0000-0002-7582-5942

Funding

Conselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeicoamento de Pessoal de Nível Superior
6 · The paper itself

Abstract

Some oxysterols were shown to promote osteogenic differentiation of mesenchymal stem cells (MSCs). Little is known about the effects of 7-ketocholesterol (7-KC) in this process. We describe its impact on human adipose tissue-derived MSC (ATMSC) osteogenic differentiation. ATMSCs were incubated with 7-KC in osteogenic or adipogenic media. Osteogenic and adipogenic differentiation was evaluated by Alizarin red and Oil Red O staining, respectively. Osteogenic (

Indexed as

Adipose TissueCell DifferentiationKetocholesterolsMesenchymal Stem CellsOsteogenesisAdipogenesisbeta CateninCells, CulturedCore Binding Factor Alpha 1 SubunitHedgehog ProteinsHumansPPAR gammaSignal TransductionSmoothened Receptor7-ketocholesterolbeta CateninCore Binding Factor Alpha 1 SubunitHedgehog ProteinsKetocholesterolsPPAR gammaRUNX2 protein, humanSmoothened ReceptorSMO protein, human7-KCadipose tissuemesenchymal stem cellosteogenic differentiationoxysterolWnt/β-catenin

Identifiers

PMID39518932
PMCPMC11545361

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.