Evidence map›Paper›PMID 39518922›Full record

ArticleInternational journal of molecular sciences2024

Elevated Netrin-4 Expression and Its Action in Infrapatellar Fat Pad.

Yui Uekusa, Manabu Mukai, Ayumi Tsukada, Dai Iwase, Jun Aikawa, Naoya Shibata, Yoshihisa Ohashi, Gen Inoue, Masashi Takaso, Kentaro Uchida

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yui UekusaDepartment of Orthopedic Surgery, School of Medicine, Kitasato University, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Kanagawa, Japan.
Manabu MukaiDepartment of Orthopedic Surgery, School of Medicine, Kitasato University, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Kanagawa, Japan.
Ayumi TsukadaDepartment of Orthopedic Surgery, School of Medicine, Kitasato University, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Kanagawa, Japan.
Dai IwaseDepartment of Orthopedic Surgery, School of Medicine, Kitasato University, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Kanagawa, Japan.
Jun AikawaDepartment of Orthopedic Surgery, School of Medicine, Kitasato University, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Kanagawa, Japan.
Naoya ShibataDepartment of Orthopedic Surgery, School of Medicine, Kitasato University, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Kanagawa, Japan.
Yoshihisa OhashiDepartment of Orthopedic Surgery, School of Medicine, Kitasato University, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Kanagawa, Japan.
Gen InoueDepartment of Orthopedic Surgery, School of Medicine, Kitasato University, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Kanagawa, Japan.ORCID 0000-0001-6500-9004
Masashi TakasoDepartment of Orthopedic Surgery, School of Medicine, Kitasato University, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Kanagawa, Japan.
Kentaro UchidaDepartment of Orthopedic Surgery, School of Medicine, Kitasato University, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Kanagawa, Japan.ORCID 0000-0001-5148-914X

Funding

a research grant for young physicians and health professionals from SRL, Inc noneGrant-in-Aid for Research Activity Start-up 23K19662Kitasato University Research Grant for Young Researchers nonePatients' Association of Kitasato University School of Medicine none
6 · The paper itself

Abstract

Knee osteoarthritis (KOA) is a degenerative joint disease characterized by inflammation and cartilage degradation. The infrapatellar fat pad (IFP), located beneath the patella within the knee joint, serves as a key anatomical structure involved in cushioning and supporting the knee. It is also an active endocrine organ that secretes various bioactive substances, potentially influencing the local inflammatory environment and contributing to KOA pathogenesis. Netrin-4 (NTN4), a protein primarily known for its role in neuronal guidance, has been implicated in various non-neuronal functions, including inflammatory processes and tissue remodeling. This study aims to explore the involvement of NTN4 in KOA, focusing on its expression in the IFP and its potential impact on disease progression. This study involved 82 patients with radiographically confirmed KOA undergoing total knee arthroplasty (TKA). The correlation between

Indexed as

Adipose TissueNetrinsOsteoarthritis, KneeAgedFemaleFibroblastsHumansKnee JointMaleMiddle AgedPatellaNetrinsNTN4 protein, humaninfrapatellar fat padNetrin-4osteoarthritis

Identifiers

PMID39518922
PMCPMC11545295

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.