Evidence map›Paper›PMID 39518918›Full record

ArticleInternational journal of molecular sciences2024

Comparative Validation of Scintillator Materials for X-Ray-Mediated Neuronal Control in the Deep Brain.

Mercedes Hildebrandt, Masanori Koshimizu, Yasuki Asada, Kansai Fukumitsu, Mahito Ohkuma, Na Sang, Takashi Nakano, Toshiaki Kunikata, Kai Okazaki, Noriaki Kawaguchi and 4 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mercedes HildebrandtDepartment of Physiology, School of Medicine, Fujita Health University, Toyoake 470-1192, Aichi, Japan.ORCID 0009-0007-9124-3567
Masanori KoshimizuResearch Institute of Electronics, Shizuoka University, Hamamatsu 432-8011, Shizuoka, Japan.ORCID 0000-0002-0905-2144
Yasuki AsadaFaculty of Radiological Technology, School of Medical Science, Fujita Health University, Toyoake 470-1192, Aichi, Japan.
Kansai FukumitsuDepartment of Physiology, School of Medicine, Fujita Health University, Toyoake 470-1192, Aichi, Japan.ORCID 0000-0001-9892-0195
Mahito OhkumaDepartment of Physiology, School of Medicine, Fujita Health University, Toyoake 470-1192, Aichi, Japan.
Na SangDepartment of Physiology, School of Medicine, Fujita Health University, Toyoake 470-1192, Aichi, Japan.
Takashi NakanoInternational Center for Brain Science, Fujita Health University, Toyoake 470-1192, Aichi, Japan.ORCID 0000-0003-0707-4486
Toshiaki KunikataDivision of Materials Science, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Nara, Japan.ORCID 0000-0002-4369-671X
Kai OkazakiDivision of Materials Science, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Nara, Japan.ORCID 0000-0003-2257-1915
Noriaki KawaguchiDivision of Materials Science, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Nara, Japan.ORCID 0000-0002-6835-9437
Takayuki YanagidaDivision of Materials Science, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, Nara, Japan.ORCID 0000-0002-7326-5849
Linyuan LianKey Laboratory of Materials Physics of Ministry of Education, School of Physics, Zhengzhou University, Zhengzhou 450052, China.
Jianbing ZhangSchool of Integrated Circuits, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0000-0003-0642-3939
Takayuki YamashitaDepartment of Physiology, School of Medicine, Fujita Health University, Toyoake 470-1192, Aichi, Japan.ORCID 0000-0002-1849-9837

Funding

Japan Science and Technology Agency JPMJFR204HJapan Society for the Promotion of Science 22H02939The Asahi Glass Foundation N.A.The Uehara Memorial Foundation N.A.
6 · The paper itself

Abstract

When exposed to X-rays, scintillators emit visible luminescence. X-ray-mediated optogenetics employs scintillators for remotely activating light-sensitive proteins in biological tissue through X-ray irradiation. This approach offers advantages over traditional optogenetics, allowing for deeper tissue penetration and wireless control. Here, we assessed the short-term safety and efficacy of candidate scintillator materials for neuronal control. Our analyses revealed that lead-free halide scintillators, such as Cs

Indexed as

BrainAnimalsDopaminergic NeuronsMaleMiceMice, Inbred C57BLNanoparticlesNeuronsOptogeneticsX-Raysdeep brain stimulationdopamineelectrophysiologynanoparticlesoptogeneticsscintillatortoxicityX-rays

Identifiers

PMID39518918
PMCPMC11547033

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.