Evidence map›Paper›PMID 39518904›Full record

ArticleInternational journal of molecular sciences2024

Wakefulness Induced by TAAR1 Partial Agonism in Mice Is Mediated Through Dopaminergic Neurotransmission.

Sunmee Park, Jasmine Heu, Marius C Hoener, Thomas S Kilduff

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Transcriptomic Analysis ofBrain sciences · 2025
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Sunmee ParkCenter for Neuroscience, Biosciences Division, SRI International, Menlo Park, CA 94025, USA.ORCID 0000-0001-6047-0774
Jasmine HeuCenter for Neuroscience, Biosciences Division, SRI International, Menlo Park, CA 94025, USA.
Marius C HoenerNeuroscience and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.ORCID 0000-0001-6510-6250
Thomas S KilduffCenter for Neuroscience, Biosciences Division, SRI International, Menlo Park, CA 94025, USA.ORCID 0000-0002-6823-0094

Funding

TAAR1-Alzheimers SupplementR01NS103529 · NINDS · SRI INTERNATIONAL · PI KILDUFF, THOMAS S · 2018 to 2022
$3.8M
Nociceptin, NOPR and Sleep/Wake ControlR01NS136808 · NINDS · SRI INTERNATIONAL · PI Thomas S Kilduff · 2024 to 2026
$2.7M
NIH HHS R01NS103529NINDS NIH HHS R01 NS103529NINDS NIH HHS R01 NS136808
6 · The paper itself

Abstract

Trace amine-associated receptor 1 (TAAR1) is a negative regulator of dopamine (DA) release. The partial TAAR1 agonist RO5263397 promotes wakefulness and suppresses NREM and REM sleep in rodents and non-human primates. We tested the hypothesis that the TAAR1-mediated effects on sleep/wake regulation were due, in part, to DA release. Male C57BL6/J mice (

Indexed as

DopamineMice, Inbred C57BLReceptors, G-Protein-CoupledWakefulnessAnimalsBenzazepinesMaleMiceOxazolesReceptors, Dopamine D1Receptors, Dopamine D2SalicylamidesSleep, REMSynaptic TransmissionTrace Amine-Associated Receptors4-(3-fluoro-2-methylphenyl)-4,5-dihydrooxazol-2-ylamineBenzazepinesDopamineeticloprideOxazolesReceptors, Dopamine D1Receptors, Dopamine D2Receptors, G-Protein-CoupledSalicylamidesSCH 23390Trace Amine-Associated Receptorsagonistsdopaminergic antagonistssleeptrace amine-associated receptor 1 (TAAR1)

Identifiers

PMID39518904
PMCPMC11547084

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.