Mucosal Addressin Cell Adhesion Molecule-1 Mediates T Cell Migration into Pancreas-Draining Lymph Nodes for Initiation of the Autoimmune Response in Type 1 Diabetes.

Yankui Li, Rachel C Gunderson, Zeyu Xu, Wenjia Ai, Fanru Shen, Jiayu Ye, Baohui Xu, Sara A Michie

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Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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2 · The registry

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5 · Who and what money

Authors and funding

8 authors.

Yankui LiDepartment of Vascular Surgery, Tianjin Medical University Second Hospital, Tianjin 300211, China.ORCID 0000-0001-8048-0910

Rachel C GundersonDepartment of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.

Zeyu XuDepartment of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.

Wenjia AiDepartment of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-5375-4557

Fanru ShenDepartment of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-4418-4588

Jiayu YeDepartment of Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.

Baohui XuDepartment of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-2857-7464

Sara A MichieDepartment of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.

Funding

NIH HHS DK067592

6 · The paper itself

Abstract

Type 1 diabetes (T1D) is an autoimmune disease that is caused by autoreactive T cell-mediated destruction of insulin-producing β cells in the pancreatic islets. Although naive autoreactive T cells are initially primed by islet antigens in pancreas-draining lymph nodes (pan-LNs), the adhesion molecules that recruit T cells into pan-LNs are unknown. We show that high endothelial venules in pan-LNs of young nonobese diabetic mice have a unique adhesion molecule profile that includes strong expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Anti-MAdCAM-1 antibody blocked more than 80% of the migration of naive autoreactive CD4

Indexed as

Cell Adhesion MoleculesCell MovementDiabetes Mellitus, Type 1Lymph NodesMice, Inbred NODMucoproteinsPancreasAnimalsAutoimmunityCD4-Positive T-LymphocytesMiceCell Adhesion MoleculesMadcam1 protein, mouseMucoproteinsadhesion moleculeregulation T cellsT cell migrationtype 1 diabetes

Identifiers

PMID39518902

DOI10.3390/ijms252111350

PMCPMC11545416

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.