ArticleDiagnostics (Basel, Switzerland)2024
Polymorphism rs564398 of the ANRIL Gene as a Coronary-Artery-Disease-Associated SNP in Diabetic Patients of the Kazakh Population.
Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Genotype-dependent metabolic and inflammatory regulation at the ANRIL locus in human primary macrophages.Molecular genetics and genomics : MGG · 2026Article
- Association of Genetic Polymorphisms with Gestational Diabetes in a Kazakh Population: A Case-Control Study.Diagnostics (Basel, Switzerland) · 2026Article
- A pilot genome-wide association study of ischemic heart disease with co-occurring arterial hypertension in a Kazakh cohort.Frontiers in genetics · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
BACKGROUND/
objectivesA cardiovascular complication of type 2 diabetes mellitus like coronary artery disease is influenced by a complex interplay between environmental, phenotypic, and genetic factors. The genetic mechanisms in the development of this pathology are not established. This study aims to evaluate the association of polymorphisms rs1011970, rs62560775, and rs564398 from the 9p21.3 locus with coronary artery disease in diabetic patients of the Kazakh population.
methodsA total of 343 people participated in the case-control study: the control group consisted of 109 people with type 2 diabetes and coronary artery disease, while the control group included 234 people. Genotyping was performed using real-time PCR. Statistical analysis was carried out using Chi-square methods and calculating odds ratios (OR) with 95% confidence intervals (CI).
resultsAccording to the results, only the rs564398 polymorphism of the ANRIL gene was associated with coronary artery disease (
conclusionsThus, this research further elicits the association of the ANRIL gene with cardiometabolic disease.
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