Evidence map›Paper›PMID 39518333›Full record

ReviewDiagnostics (Basel, Switzerland)2024

Rare Head and Neck Cancers and Pathological Diagnosis Challenges: A Comprehensive Literature Review.

Daria Maria Filippini, Francesca Carosi, Giulia Querzoli, Matteo Fermi, Ilaria Ricciotti, Gabriele Molteni, Livio Presutti, Maria Pia Foschini, Laura Deborah Locati

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Challenges in pathological diagnosis of rare head and neck cancers: National survey and retrospective study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daria Maria FilippiniDivision of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria Sant'Orsola Malpighi, 40138 Bologna, Italy.ORCID 0000-0003-3328-7282
Francesca CarosiDivision of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria Sant'Orsola Malpighi, 40138 Bologna, Italy.
Giulia QuerzoliDepartment of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, Università di Bologna, 40138 Bologna, Italy.
Matteo FermiDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-2727-0321
Ilaria RicciottiDivision of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria Sant'Orsola Malpighi, 40138 Bologna, Italy.
Gabriele MolteniDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0001-7764-2122
Livio PresuttiDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Maria Pia FoschiniUnit of Anatomic Pathology, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bellaria Hospital, 40139 Bologna, Italy.ORCID 0000-0001-7079-7260
Laura Deborah LocatiDepartment of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0003-3315-2580

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck cancers (HNCs) arise from anatomically adjacent sites and subsites, with varying etiological factors, diagnostic strategies, prognoses, and treatment approaches. While conventional squamous cell carcinoma (SCC) is the most common histology in the head and neck district, HNCs encompass a variety of rare histopathological entities, categorized into epithelial tumors such as salivary gland cancers, sinonasal tumors, neuroendocrine tumors, malignant odontogenic tumors, and SCC variants versus non-epithelial tumors including soft tissue sarcomas, mucosal melanomas, and hematological malignancies. Rare HNCs (R-HNCs) represent a diagnostic and clinical challenge, requiring histopathological expertise, the availability of peculiar molecular analysis, and the personalization of local and systemic treatments, all guided by a multidisciplinary tumor board. Here, we provide a comprehensive literature review on R-HNCs, emphasizing key histopathological and molecular characteristics that are crucial for guiding treatment decisions. An insight about the latest developments in systemic treatments is also reported.

Indexed as

head and neck cancerhistopathological diagnosismolecular diagnosticsmultidisciplinary carerare cancers

Identifiers

PMID39518333
PMCPMC11544949

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.