Evidence map›Paper›PMID 39518103›Full record

ArticleCancers2024

TYK2 Protein Expression and Its Potential as a Tissue-Based Biomarker for the Diagnosis of Colorectal Cancer.

Łukasz Zadka, Adam Ustaszewski, Natalia Glatzel-Plucińska, Agnieszka Rusak, Izabela Łaczmańska, Katarzyna Ratajczak-Wielgomas, Alicja Kmiecik, Aleksandra Piotrowska, Katarzyna Haczkiewicz-Leśniak, Agnieszka Gomułkiewicz and 2 more

Abstract read
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In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Łukasz ZadkaDivision of Ultrastructural Research, Faculty of Medicine, Wroclaw Medical University, Chałubińskiego 6a, 50-368 Wrocław, Poland.ORCID 0000-0001-5217-1635
Adam UstaszewskiInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznań, Poland.ORCID 0000-0002-9542-0029
Natalia Glatzel-PlucińskaDivision of Histology and Embryology, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wrocław, Poland.
Agnieszka RusakDivision of Histology and Embryology, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wrocław, Poland.ORCID 0000-0001-9587-0575
Izabela ŁaczmańskaDepartment of Genetics, Faculty of Medicine, Wroclaw Medical University, 50-368 Wrocław, Poland.
Katarzyna Ratajczak-WielgomasDivision of Histology and Embryology, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wrocław, Poland.ORCID 0000-0001-6175-2204
Alicja KmiecikDivision of Histology and Embryology, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wrocław, Poland.
Aleksandra PiotrowskaDivision of Histology and Embryology, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wrocław, Poland.ORCID 0000-0003-4093-7386
Katarzyna Haczkiewicz-LeśniakDivision of Ultrastructural Research, Faculty of Medicine, Wroclaw Medical University, Chałubińskiego 6a, 50-368 Wrocław, Poland.ORCID 0000-0001-9036-8842
Agnieszka GomułkiewiczDivision of Histology and Embryology, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wrocław, Poland.ORCID 0000-0003-2256-1055
Magdalena Kostrzewska-PoczekajInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznań, Poland.ORCID 0000-0001-8099-3839
Piotr DzięgielDivision of Histology and Embryology, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wrocław, Poland.

Funding

National Science Center UMO-2017/27/N/NZ5/02020
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe aim of this study was to examine the expression of TYK2 in colorectal cancer (CRC) and to determine the potential diagnostic and prognostic significance of this kinase.

methodsDigital image analysis was performed to assess immunohistochemical TYK2 reactivity.

resultsThere were significant differences for all positive pixels between CRC and normal colonic mucosa, with higher TYK2 expression levels observed in surgical margins than in adenocarcinomas (

conclusionsTYK2 protein expression may bring diagnostic value in patients diagnosed with CRC.

Indexed as

colorectal cancerCRCimmunohistochemistrytyrosine kinase 2

Identifiers

PMID39518103
PMCPMC11545102

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.