Evidence map›Paper›PMID 39518078›Full record

ArticleCancers2024

Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes.

Isaac Cebrecos, Ines Torras, Helena Castillo, Claudia Pumarola, Sergi Ganau, Carla Sitges, Sergi Vidal-Sicart, Francesco Schettini, Esther Sanfeliu, Ignacio Loinaz and 5 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Predicting the Probability of Residual Axillary Nodal Metastases in Patients With Breast Cancer Treated With Neoadjuvant Chemotherapy.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Isaac CebrecosDepartment of Obstetrics and Gynecology and Neonatology, Hospital Clinic of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-9333-3642
Ines TorrasDepartment of Obstetrics and Gynecology and Neonatology, Hospital Clinic of Barcelona, 08036 Barcelona, Spain.
Helena CastilloDepartment of Obstetrics and Gynecology and Neonatology, Hospital Clinic of Barcelona, 08036 Barcelona, Spain.
Claudia PumarolaDepartment of Obstetrics and Gynecology and Neonatology, Hospital Clinic of Barcelona, 08036 Barcelona, Spain.
Sergi GanauDepartment of Radiology, Hospital Clinic of Barcelona, 08036 Barcelona, Spain.
Carla SitgesDepartment of Radiology, Hospital Clinic of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-0086-4429
Sergi Vidal-SicartDepartment of Nuclear Medicine, Hospital Clinic of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-6303-3606
Francesco SchettiniFaculty of Medicine, University of Barcelona, 08007 Barcelona, Spain.ORCID 0000-0001-6561-1919
Esther SanfeliuFaculty of Medicine, University of Barcelona, 08007 Barcelona, Spain.
Ignacio LoinazDepartment of Obstetrics and Gynecology and Neonatology, Hospital Clinic of Barcelona, 08036 Barcelona, Spain.ORCID 0009-0000-6778-4725
Marta GarciaDepartment of Obstetrics and Gynecology and Neonatology, Hospital Clinic of Barcelona, 08036 Barcelona, Spain.
Gabriela OsesDepartment of Radiation Oncology, Hospital Clinic of Barcelona, 08036 Barcelona, Spain.
Meritxell MollaFaculty of Medicine, University of Barcelona, 08007 Barcelona, Spain.ORCID 0000-0001-6215-2251
Maria VidalFaculty of Medicine, University of Barcelona, 08007 Barcelona, Spain.
Eduard MensionDepartment of Obstetrics and Gynecology and Neonatology, Hospital Clinic of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-1227-1137

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe aim of the study was to determine the clinical value of the sentinel lymph node ratio (SLN-R) in predicting additional positive lymph nodes during axillary lymph node dissection (ALND) in breast cancer patients following neoadjuvant chemotherapy (NAC).

methodsA cross-sectional study was performed at a single institution evaluating data from 1521 BC patients. Inclusion criteria comprised cT1/cT4, cN0/cN1 status with positive post-NAC axillary staging by SLN/TAD, respectively, and subsequent ALND.

resultsThe study included 118 patients, divided into two groups based on the presence or absence of additional node metastasis at ALND: 39 in the residual disease group (RD) and 79 in the non-residual disease group (nRD). Univariate logistic regression analysis of SLN-R was conducted to assess its predictive value, yielding an odds ratio (OR) of 7.79 (CI 1.92-29.5,

conclusionsThe study concludes that SLN-R is a valuable predictor for determining the omission of ALND in cases where SLN/TAD is positive after NAC. This metric, in combination with other clinical variables, could help develop a nomogram to spare patients from ALND.

Indexed as

axillary lymph node dissectionbreast cancerneoadjuvant chemotherapysentinel lymph nodetargeted axillary dissection

Identifiers

PMID39518078
PMCPMC11545455

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.