Evidence map›Paper›PMID 39518045›Full record

ArticleCancers2024

Rac1 GTPase Regulates the βTrCP-Mediated Proteolysis of YAP Independently of the LATS1/2 Kinases.

Chitra Palanivel, Tabbatha N Somers, Bailey M Gabler, Yuanhong Chen, Yongji Zeng, Jesse L Cox, Parthasarathy Seshacharyulu, Jixin Dong, Ying Yan, Surinder K Batra and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chitra PalanivelDepartment Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Tabbatha N SomersDepartment Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Bailey M GablerDepartment Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Yuanhong ChenEppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Yongji ZengEppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-1184-1900
Jesse L CoxDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-4590-7381
Parthasarathy SeshacharyuluDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-2348-3901
Jixin DongEppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-2757-4464
Ying YanDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-3546-3991
Surinder K BatraDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0001-9470-9317
Michel M OuelletteDepartment Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0001-7265-6779

Funding

Research Pilot Project ProgramP30GM106397 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI JOHNSON, KEITH R · 2013 to 2017
$4.9M
Rac1 GTPase in tumorigenesis and progression of pancreatic cancerR01CA206444 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K., OUELLETTE, MICHEL M · 2016 to 2020
$1.9M
PR55-alpha controlled PP2A in the regulation of the Hippo/YAP pathwayR01GM143329 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI YAN, YING · 2021 to 2024
$1.3M
NCI NIH HHS R01 CA206444Nebraska DHHS LB506 2022-42NIGMS NIH HHS P30 GM106397NIGMS NIH HHS R01 GM143329NIH HHS P30 GM106397NIH HHS R01 CA206444NIH HHS R01 GM143329
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

GTPaseHippopancreatic cancerRac1Rasubiquitin ligasesYAPβTrCP

Identifiers

PMID39518045
PMCPMC11545309

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.