Evidence map›Paper›PMID 39518037›Full record

ReviewCancers2024

On the Way to Accounting for Lung Modulation Effects in Particle Therapy of Lung Cancer Patients-A Review.

Matthias Witt, Uli Weber, Veronika Flatten, Jessica Stolzenberg, Rita Engenhart-Cabillic, Klemens Zink, Kilian-Simon Baumann

Abstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthias WittInstitute of Medical Physics and Radiation Protection, University of Applied Sciences, 35390 Giessen, Germany.ORCID 0000-0002-1304-9079
Uli WeberInstitute of Medical Physics and Radiation Protection, University of Applied Sciences, 35390 Giessen, Germany.ORCID 0000-0002-8147-0084
Veronika FlattenSun Nuclear, Mirion Medical Company, Melbourne, FL 32940, USA.ORCID 0000-0003-4963-6838
Jessica StolzenbergInstitute of Medical Physics and Radiation Protection, University of Applied Sciences, 35390 Giessen, Germany.
Rita Engenhart-CabillicDepartment of Radiotherapy and Radiation Oncology, Marburg University Hospital, 35043 Marburg, Germany.ORCID 0000-0002-7444-9033
Klemens ZinkInstitute of Medical Physics and Radiation Protection, University of Applied Sciences, 35390 Giessen, Germany.ORCID 0000-0001-5785-4101
Kilian-Simon BaumannInstitute of Medical Physics and Radiation Protection, University of Applied Sciences, 35390 Giessen, Germany.ORCID 0000-0003-1223-523X

Funding

Deutsche Forschungsgemeinschaft 511593530Federal Ministry of Education and Research 02NUK076AHessen State Ministry of Higher Education, Research, and the Arts (HMWK) LOEWE/2/16/519/03/09.001(0001)/101
6 · The paper itself

Abstract

Particle therapy presents a promising alternative to conventional photon therapy for treating non-small cell lung cancer (NSCLC). However, the heterogeneous structure of lung tissue leads to the degradation of the Bragg peak and thereby to the degradation of the dose distribution. This review offers a comprehensive overview of the models developed to account for these modulation effects. It summarizes studies focused on determining modulation power as a predictor of this so-called lung modulation. In addition, the review covers early investigations on dose uncertainties caused by lung modulation in CT-based lung phantoms and patient anatomies and discusses future challenges in integrating these solutions into clinical treatment planning routines.

Indexed as

dose calculationdose degradationlung cancerlung modulation effectsMonte Carloparticle therapytreatment planning

Identifiers

PMID39518037
PMCPMC11545780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.