Evidence map›Paper›PMID 39518031›Full record

ArticleCancers2024

Ethnicity and Socioeconomic Disparities in Clinical Trial Participation for Ovarian Cancer: A Retrospective Observational Study in London.

Karim H El-Shakankery, Joanna Kefas, Kieran Palmer, Andrew Houston, Uma Mukherjee, Kangbo Gao, Weiteen Tan, Shanthini M Crusz, Michael J Flynn, Jonathan A Ledermann and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Karim H El-ShakankeryDepartment of Medical Oncology, University College London Hospital, London NW1 2BU, UK.ORCID 0000-0002-7516-1541
Joanna KefasDepartment of Medical Oncology, University College London Hospital, London NW1 2BU, UK.ORCID 0000-0002-3746-6942
Kieran PalmerSt Bartholomew's Hospital, Barts Health NHS Trust, London EC1A 7BE, UK.ORCID 0000-0003-3710-1588
Andrew HoustonBarts Life Sciences, Barts Health NHS Trust, London EC1A 7BE, UK.
Uma MukherjeeDepartment of Medical Oncology, University College London Hospital, London NW1 2BU, UK.ORCID 0000-0001-6693-8788
Kangbo GaoBarts and The London School of Medicine and Dentistry, Garrod Building, Turner Street, Whitechapel, London E1 2AD, UK.ORCID 0000-0002-9562-9412
Weiteen TanSt Bartholomew's Hospital, Barts Health NHS Trust, London EC1A 7BE, UK.
Shanthini M CruszSt Bartholomew's Hospital, Barts Health NHS Trust, London EC1A 7BE, UK.
Michael J FlynnDepartment of Medical Oncology, University College London Hospital, London NW1 2BU, UK.
Jonathan A LedermannDepartment of Medical Oncology, University College London Hospital, London NW1 2BU, UK.ORCID 0000-0003-3799-3539
Michelle LockleyDepartment of Medical Oncology, University College London Hospital, London NW1 2BU, UK.
Mary McCormackDepartment of Medical Oncology, University College London Hospital, London NW1 2BU, UK.ORCID 0000-0002-8429-5744
Nicola MacDonaldDepartment of Medical Oncology, University College London Hospital, London NW1 2BU, UK.ORCID 0000-0003-0631-6359
Shibani NicumDepartment of Medical Oncology, University College London Hospital, London NW1 2BU, UK.ORCID 0000-0003-1125-405X
Michael John DevlinSt Bartholomew's Hospital, Barts Health NHS Trust, London EC1A 7BE, UK.ORCID 0000-0002-4481-1716
Rowan E MillerDepartment of Medical Oncology, University College London Hospital, London NW1 2BU, UK.ORCID 0000-0002-2400-1716

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEthnic and socioeconomic disparities in cancer outcomes are exacerbated by clinical trial underrepresentation. This study aims to identify inequalities in ethnicity and socioeconomic features among ovarian cancer clinical trial participants in two London cancer centres.

methodsAll ovarian cancer patients treated between 2017 and 2022 were included. Patients participating in clinical trials were classified as the trial population (TP); the remainder were considered the non-trial population (NTP). Data on disease characteristics and sociodemographic features, including ethnicity and Indices of Multiple Deprivation (IMD) deciles, were accessed from electronic patient records.

resultsOf the 892 patients, 212 (24%) were enrolled in trials: 87 in Phase II, 103 in Phase III, and 21 in prospective, non-investigational medicinal product trials. The TP were more likely to be of White ethnicity (72.6% vs. 57.5%;

conclusionsEthnic and socioeconomic inequalities affect trial participation, potentially worsening health disparities in ovarian cancer patients. Strategies to overcome trial recruitment barriers for underserved groups are needed to improve the equity of care.

Indexed as

cancer mortalityclinical trialsethnicityhealth inequalitieshealth outcomessocioeconomic status

Identifiers

PMID39518031
PMCPMC11545063

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.