Evidence map›Paper›PMID 39518021›Full record

ArticleCancers2024

Molecular Alterations in Paired Epithelial Ovarian Tumors in Patients Treated with Neoadjuvant Chemotherapy.

Adamantia Nikolaidi, Eirini Papadopoulou, Dimitrios Haidopoulos, Michalis Liontos, Elena Fountzilas, Georgios Tsaousis, Kalliroi Goula, Eleftheria Tsolaki, Athina Christopoulou, Ioannis Binas and 7 more

Abstract read
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In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Adamantia NikolaidiOncology Clinic, Mitera Hospital, 15123 Athens, Greece.ORCID 0000-0003-2057-9585
Eirini PapadopoulouGenekor Medical SA, 15344 Athens, Greece.
Dimitrios HaidopoulosFirst Department of Obstetrics and Gynaecology, Division of Gynecologic Oncology, Alexandra Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Michalis LiontosDepartment of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0001-7192-4575
Elena FountzilasDepartment of Medical Oncology, St Luke's Clinic, 55236 Thessaloniki, Greece.
Georgios TsaousisGenekor Medical SA, 15344 Athens, Greece.ORCID 0000-0002-8975-8779
Kalliroi GoulaDepartment of Pathology, Alexandra Hospital, 11528 Athens, Greece.
Eleftheria TsolakiLaboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece.
Athina ChristopoulouMedical Oncology Unit, S. Andrew Hospital, 26332 Patras, Greece.
Ioannis BinasSecond Department of Medical Oncology, Metropolitan Hospital, 18547 Piraeus, Greece.
Sofia StamatopoulouOncology Unit, General Hospital of Kalamata, 24100 Kalamata, Greece.
Anna KoumarianouHematology-Oncology Unit, Fourth Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0002-4159-2511
Sofia KarageorgopoulouThird Department of Medical Oncology, IASO Clinic, 15123 Athens, Greece.ORCID 0000-0002-5628-3121
Anna GoussiaDepartment of Pathology, University Hospital of Ioannina, 45500 Ioannina, Greece.
Amanda PsyrriSection of Medical Oncology, Department of Internal Medicine, Attikon University Hospital, Faculty of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Christos PapadimitriouOncology Unit, Aretaieion University Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0001-8084-0445
Helen GogasFirst Department of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-0451-2885

Funding

Hellenic Cooperative Oncology Group (HeCOG) TR_NACT_OV/17Hellenic Society for Medical Oncology (HeSMO) N/A
6 · The paper itself

Abstract

backgroundNeoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) and adjuvant chemotherapy is a therapeutic choice for women with advanced ovarian cancer. Whether NACT affects the tumor's molecular profile has not been determined.

methodsThis was a retrospective study of patients with advanced-stage epithelial ovarian cancer treated with NACT at oncology departments affiliated with the Hellenic Cooperative Oncology Group (HeCOG). Tumor molecular profiling was performed on formalin-fixed and paraffin-embedded (FFPE) tumor pre- and post-NACT tissues. Homologous recombination deficiency (HRD), tumor-infiltrating lymphocytes (TILs), tumor molecular alterations, and tumor mutational burden (TMB) via next-generation sequencing analysis were assessed.

resultsOverall, tumors from 36 patients were assessed, and molecular profiling was evaluated in 20 paired tumor samples. HRD positivity exhibited no significant change between pre- and post-NACT tumors. The BRCA1/2 mutational status remained constant, irrespective of the treatment administration. Pre-NACT tumors tended to exhibit a lower percentage of intratumoral TILs compared to post-NACT tumors (

conclusionThis study provides insights into the effect of NACT on the tumor molecular landscape. While BRCA1/2 and HRD status remained stable, an increase in TIL proportion and changes in the mutational profiles were observed post-treatment.

Indexed as

chemotherapy response score (CRS)genomic alterationsgenomic instability score (GIS)neoadjuvant chemotherapy (NACT)next-generation sequencing (NGS)tumor cell content (TCC)

Identifiers

PMID39518021
PMCPMC11545381

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.