Novel Applications in Controlled Drug Delivery Systems by Integrating Osmotic Pumps and Magnetic Nanoparticles.

David Navarro-Tumar, Belén García-Merino, Cristina González-Fernández, Inmaculada Ortiz, Ma-Fresnedo San-Román, Eugenio Bringas

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In one paragraph

Review in Sensors (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

David Navarro-TumarDepartment of Chemical and Biomolecular Engineering, ETSIIT, University of Cantabria, Avda. de los Castros, s/n, 39005 Santander, Spain.

Belén García-MerinoDepartment of Chemical and Biomolecular Engineering, ETSIIT, University of Cantabria, Avda. de los Castros, s/n, 39005 Santander, Spain.ORCID 0000-0002-1620-2251

Cristina González-FernándezDepartment of Chemical and Biomolecular Engineering, ETSIIT, University of Cantabria, Avda. de los Castros, s/n, 39005 Santander, Spain.ORCID 0000-0002-1571-057X

Inmaculada OrtizDepartment of Chemical and Biomolecular Engineering, ETSIIT, University of Cantabria, Avda. de los Castros, s/n, 39005 Santander, Spain.

Ma-Fresnedo San-RománDepartment of Chemical and Biomolecular Engineering, ETSIIT, University of Cantabria, Avda. de los Castros, s/n, 39005 Santander, Spain.ORCID 0000-0002-3638-2448

Eugenio BringasDepartment of Chemical and Biomolecular Engineering, ETSIIT, University of Cantabria, Avda. de los Castros, s/n, 39005 Santander, Spain.

Funding

Ministerio de Ciencia, Innovación y Universidades; Agencia Estatal de Investigación PID2020-115409RB-I00Ministerio de Ciencia, Innovación y Universidades; Agencia Estatal de Investigación; European Union Next Generation EU/PRTR PDC2021-673 120786-I00Ministerio de Ciencia, Innovación y Universidades; Agencia Estatal de Investigación; European Union Next Generation EU/PRTR TED2021-129874B-I00Spanish Ministry of Science, Innovation and Universities; Ministerio de Ciencia, Innovación y Universidades; Agencia Estatal de Investigación; ESF Investing in your future PRE2019-089339Spanish Ministry of Universities; European Union-NextGenerationEU Margarita Salas postdoctoral fellowship (grants for the requalification of the Spanish uni-681 versity system for 2021-2023, University of Cantabria)University of Cantabria Concepción Arenal predoctoral contract UC-23-28

6 · The paper itself

Abstract

The alarming rise in chronic diseases worldwide highlights the urgent need to overcome the limitations of conventional drug delivery systems. In this context, osmotic pumps are able to release drugs by differential osmotic pressure, achieving a controlled rate independent of physiological factors and reducing the dosing frequency. As osmotic pumps are based on the phenomenon of osmosis, the choice of high osmolality draw solutions (DSs) is a critical factor in the successful delivery of the target drug. Therefore, one alternative that has received particular attention is the formulation of DSs with magnetic nanoparticles (MNPs) due to their easy recovery, negligible reverse solute flux (RSF), and their possible tailor-made functionalization to generate high osmotic gradients. In this work, the possible integration of DSs formulated with MNPs in controlled drug delivery systems is discussed for the first time. In particular, the main potential advantages that these novel medical devices could offer, including improved scalability, regeneration, reliability, and enhanced drug delivery performance, are provided and discussed. Thus, the results of this review may demonstrate the potential of MNPs as osmotic agents, which could be useful for advancing the design of osmotic pump-based drug delivery systems.

Indexed as

Drug Delivery SystemsMagnetite NanoparticlesOsmosisHumansOsmolar ConcentrationOsmotic PressureMagnetite Nanoparticlesdraw solutionsdrug deliveryforward osmosismagnetic nanoparticlesmedical devicesosmotic pressureosmotic pumps

Identifiers

PMID39517939

DOI10.3390/s24217042

PMCPMC11548579

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