Evidence map›Paper›PMID 39517020›Full record

ArticleGeneral thoracic and cardiovascular surgery cases2024

Epithelioid pleural mesothelioma successfully treated with perioperative immunotherapy: a case report.

Gaku Yamazaki, Aki Fujiwara-Kuroda, Jun Muto, Hideki Ujiie, Masato Aragaki, Megumi Furuta, Sakurako Ohno, Kanako C Hatanaka, Yutaka Hatanaka, Yoshihiro Matsuno and 1 more

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Article in General thoracic and cardiovascular surgery cases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Gaku YamazakiDepartment of Thoracic Surgery, Hokkaido University Hospital, Kita-Ku, Sapporo, Hokkaido, N14W5, 060-8648, Japan.
Aki Fujiwara-KurodaDepartment of Thoracic Surgery, Hokkaido University Hospital, Kita-Ku, Sapporo, Hokkaido, N14W5, 060-8648, Japan.
Jun MutoDepartment of Thoracic Surgery, Hokkaido University Hospital, Kita-Ku, Sapporo, Hokkaido, N14W5, 060-8648, Japan.
Hideki UjiieDepartment of Thoracic Surgery, Hokkaido University Hospital, Kita-Ku, Sapporo, Hokkaido, N14W5, 060-8648, Japan.
Masato AragakiDepartment of Thoracic Surgery, Hokkaido University Hospital, Kita-Ku, Sapporo, Hokkaido, N14W5, 060-8648, Japan.
Megumi FurutaDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Sakurako OhnoDepartment of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.
Kanako C HatanakaCenter for Development of Advanced Diagnostics, Hokkaido University Hospital, Sapporo, Japan.
Yutaka HatanakaCenter for Development of Advanced Diagnostics, Hokkaido University Hospital, Sapporo, Japan.
Yoshihiro MatsunoDepartment of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.
Tatsuya KatoDepartment of Thoracic Surgery, Hokkaido University Hospital, Kita-Ku, Sapporo, Hokkaido, N14W5, 060-8648, Japan. katotatu7@msn.com.ORCID http://orcid.org/0000-0003-4063-0042

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPleural mesothelioma, characterized by a dismal prognosis even with multimodal therapy, has seen emerging interest in immune checkpoint inhibitors (ICIs) due to their demonstrated efficacy. Here, we present a case of epithelioid-type pleural mesothelioma with chest wall invasion treated with definitive ICI therapy, resulting in a remarkable pretreatment effect. CASE PRESENTATION: A 46-year-old man was diagnosed with an abnormal chest shadow on a medical check, and a computed tomography scan showed pleural thickening at the dorsal right upper chest wall. One of the nodules was suspected to have invaded the chest wall. A needle biopsy revealed epithelioid-type pleural mesothelioma. After five cycles of nivolumab plus ipilimumab, he underwent right pleurectomy/decortication (P/D). Pathological examination revealed a significant treatment effect, showing numerous lymphocytes infiltrating the tumor nodule and viable tumor cells localized at approximately 6 mm.

conclusionAlthough further accumulation of cases is required to evaluate the effectiveness and case selection, P/D after immunotherapy is a useful curative treatment option for advanced pleural mesothelioma.

Indexed as

Immune checkpoint inhibitorPleural mesotheliomaPleurectomy/decorticationSalvage surgery

Identifiers

PMID39517020
PMCPMC11533446

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