Evidence map›Paper›PMID 39516998›Full record

ArticleGeneral thoracic and cardiovascular surgery cases2024

A case of salvage surgery following chemoradiotherapy and durvalumab for initially unresectable superior sulcus tumor with N3 involvement.

Takehiko Manabe, Masatoshi Kanayama, Hiroki Matsumiya, Katsuma Yoshimatsu, Masataka Mori, Natsumasa Nishizawa, Akihiro Taira, Masaru Takenaka, Koji Kuroda, Koichi Azuma and 1 more

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Article in General thoracic and cardiovascular surgery cases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Takehiko ManabeSecond Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan. t-manabe-ts@med.uoeh-u.ac.jp.ORCID http://orcid.org/0000-0002-7444-6158
Masatoshi KanayamaSecond Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Hiroki MatsumiyaSecond Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Katsuma YoshimatsuSecond Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Masataka MoriSecond Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Natsumasa NishizawaSecond Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Akihiro TairaSecond Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Masaru TakenakaSecond Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Koji KurodaSecond Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Koichi AzumaDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Fumihiro TanakaSecond Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDurvalumab after chemoradiation (PACIFIC regimen) provides favorable treatment outcomes for unresectable stage III non-small cell lung cancer (NSCLC). The feasibility of salvage surgery after the PACIFIC regimen has been reported in some studies; however, its efficacy remains unclear. We herein present the first case of salvage surgery after the PACIFIC regimen for a superior sulcus tumor with N3 involvement, in which a pathological complete response was achieved. CASE PRESENTATION: A 53-year-old man with a left superior sulcus tumor with N3 (# 1L, #4R) involvement (adenocarcinoma, clinical T3N3M0/IIIC) underwent concurrent chemoradiotherapy (2 cycles of cisplatin plus vinorelbine with 60 Gy radiotherapy) followed by durvalumab treatment for 1 year at a previous hospital. The PACIFIC regimen provided a significant primary tumor shrinkage (diameter 3.1 cm to 0.5 cm) with the disappearance of 18F-fluorodeoxyglucose uptake in all nodes. Six months after the end of the PACIFIC regimen, only the primary tumor showed enlargement (diameter 0.5 cm to 2.0 cm). Accordingly, local tumor recurrence was suspected. Salvage surgery (left upper lobectomy with combined chest wall resection [1st to 4th rib]) was performed. The histological examination revealed no viable tumor cells (ypT0N0M0). At 7 months after salvage surgery, the patient remains alive with no signs of tumor recurrence.

conclusionsThe present case suggests that salvage surgery may be feasible after the PACIFIC regimen for superior sulcus tumors. A long-term follow-up is essential to determine the efficacy of salvage surgery.

Indexed as

Immune checkpoint inhibitorLung cancerPACIFIC trialSalvage surgerySuperior sulcus tumor

Identifiers

PMID39516998
PMCPMC11533432

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