Evidence map›Paper›PMID 39516707›Full record

ArticleBone marrow transplantation2025

Mismatched unrelated donors allogeneic hematopoietic stem cell transplantation with antithymocyte globulin for hematological malignancies: a multicenter retrospective study in China.

Lin Li, Yi Chen, Ting Chen, Yajing Xu, Panpan Zhu, Jimin Shi, Weihua Zhai, Yanmin Zhao, Yang Xu, Xiaoyu Lai and 16 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Lin Li *Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang, CN, China.
Yi Chen *Department of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, CN, China.
Ting Chen *Medical Center of Hematology, Xinqiao Hospital, Chongqing, CN, China.
Yajing Xu *Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, CN, China.
Panpan ZhuBone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang, CN, China.
Jimin ShiBone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang, CN, China.
Weihua ZhaiState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, CN, China.
Yanmin ZhaoBone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang, CN, China.
Yang XuDepartment of Hematology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, CN, China.
Xiaoyu LaiBone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang, CN, China.
Jian YuBone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang, CN, China.ORCID 0000-0002-8704-1571
Lizhen LiuBone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang, CN, China.
Xiaolu SongZhejiang Provincial People's Hospital, Hematology and Hematopoietic Stem Cell Transplant Center, Hangzhou, Zhejiang, CN, China.
Ting YangDepartment of Hematology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, CN, China.
Ying LuThe Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang, CN, China.
Kaiqian YangDepartment of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, CN, China.
Yimei FengMedical Center of Hematology, Xinqiao Hospital, Chongqing, CN, China.
Xiaofei NiState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, CN, China.
Jianping LanZhejiang Provincial People's Hospital, Hematology and Hematopoietic Stem Cell Transplant Center, Hangzhou, Zhejiang, CN, China.
Xi QiuDepartment of Hematology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, CN, China.
Yicheng ZhangDepartment of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, CN, China.
Songfu JiangDepartment of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, CN, China.
He HuangBone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang, CN, China. huanghe@zju.edu.cn.ORCID 0000-0002-2723-1621
Erlie JiangState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, CN, China. Jiangerlie@ihcams.ac.cn.ORCID 0000-0003-0237-6063
Xi ZhangMedical Center of Hematology, Xinqiao Hospital, Chongqing, CN, China. zhangxxi@sina.com.ORCID 0000-0002-8548-2832
Yi LuoBone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang, CN, China. luoyijr@zju.edu.cn.ORCID 0000-0001-7051-219X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) utilizing mismatched unrelated donors (MMUD) present a vital option for patients with hematologic malignancies without human leukocyte antigen (HLA)-matched donors. This multicenter retrospective study encompassed 211 adults with hematological malignancies receiving allo-HSCT with antithymocyte globulin (ATG) from ≥1 HLA locus MMUD. The findings revealed cumulative incidences of II-IV acute graft-versus-host disease (GVHD) at 180 days at 26.5%, and III-IV acute GVHD at 12.3%, with 3-year cumulative incidences for total and moderate-severe chronic GVHD at 37.0% and 21.0%. The 3-year non-relapse mortality (NRM) and relapse rates were 19.7% and 25.8%. The study reported a 3-year overall survival (OS) rate of 63.1%, a disease-free survival (DFS) rate of 54.5%, and a GVHD-free, relapse-free survival (GRFS) rate of 40.8%. Administration of a lower-dose ATG-Genzyme (ATG-G, ≤ 6 mg/kg) correlated with improved engraftment without significantly affecting survival, relapse, or viral reactivation rates. The quantity of HLA mismatches did not impact engraftment, GVHD, viral reactivation, OS, DFS, GRFS, relapse, or NRM. In conclusion, MMUD allo-HSCT with ATG demonstrates favorable outcomes for patients with hematological malignancies, with no evident correlation between the degree of mismatch and post-transplantation results. Utilizing a lower dose of ATG-G ( ≤ 6 mg/kg) proved efficacious, delivering comparable clinical advantage.

Indexed as

Antilymphocyte SerumHematologic NeoplasmsHematopoietic Stem Cell TransplantationTransplantation ConditioningUnrelated DonorsAdolescentAdultAgedAllograftsChinaDisease-Free SurvivalFemaleGraft vs Host DiseaseHumansMaleMiddle AgedAntilymphocyte Serum

Identifiers

PMID39516707

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.