Evidence map›Paper›PMID 39516668›Full record

Trial reportCNS neuroscience & therapeutics2024

Effects of Transcranial Direct Current Stimulation Targeting Dorsolateral Prefrontal Cortex and Orbitofrontal Cortex on Somatic Symptoms in Patients With Major Depressive Disorder: A Randomized, Double-Blind, Controlled Clinical Trial.

Shuxiang Shi, Haijing Huang, Mengke Zhang, Yiming Chen, Weichieh Yang, Fan Wang, Shuqi Kong, Ni Zhou, Zheyi Wei, Shentse Chen and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shuxiang ShiShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Haijing HuangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mengke ZhangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yiming ChenShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weichieh YangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-5521-2794
Fan WangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shuqi KongShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ni ZhouShanghai Hongkou Mental Health Center, Shanghai, China.
Zheyi WeiShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shentse ChenShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dongbin LyuShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chenglin WuShanghai Pudong New Area Mental Health Center, Shanghai, China.
Qinte HuangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qinting ZhangShanghai Key Lab of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai, China.
Wu HongShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-9980-2481

Funding

National Key Research and Development Program of China 2022YFC3302001Research Physician Program of Shanghai Mental Health Center 2021-YJXYS-06Science and Technology Innovation Project of Shanghai Jiao Tong University School of Medicine WK2017Shanghai "Science and Technology Innovation Action Plan" Medical Innovation Research 21Y11905600Shanghai "Science and Technology Innovation Action Plan" Natural Science Foundation of Shanghai 21ZR1455100STI2030-Major Projects 2021ZD0200800
6 · The paper itself

Abstract

aimThere is a lack of research on transcranial direct current stimulation (tDCS) for the treatment of somatic symptoms in major depressive disorder (MDD) and the suitable stimulating brain region. We investigated the efficacy of tDCS targeting the dorsolateral prefrontal cortex (DLPFC) versus orbitofrontal cortex (OFC) on depressive somatic symptoms and somatic anxiety in patients with MDD and aimed to identify the appropriate stimulating brain regions.

methodsIn this randomized, double-blind, sham-controlled study, a total of 70 patients diagnosed with MDD were randomly allocated into DLPFC group, OFC group, and Sham group. Subjects participated in 2 weeks of 10 primary interventions and subsequently 2-week maintenance interventions weekly (20 min, 2 mA).

resultsThe DLPFC group showed a more significant improvement in somatic symptoms compared to the Sham group at week 2. At the maintenance and follow-up stages, the DLPFC group outperformed the Sham and OFC groups, but the difference with the Sham group was not significant. Neither active group demonstrated superiority over the Sham group in improving depression and anxiety.

conclusionIn conclusion, the tDCS targeting DLPFC may be a potentially effective therapeutic target for alleviating somatic symptoms in patients with MDD.

Indexed as

Dorsolateral Prefrontal CortexMajor Depressive DisorderTranscranial Direct Current StimulationAdultDouble-Blind MethodFemaleHumansMaleMiddle AgedPrefrontal CortexPsychiatric Status Rating ScalesTreatment OutcomeYoung Adultmajor depressive disordersomatic anxietysomatic symptomstranscranial direct current stimulation

Identifiers

PMID39516668
PMCPMC11549028

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.