Evidence map›Paper›PMID 39516465›Full record

ReviewNPJ Parkinson's disease2024

A framework for translational therapy development in deep brain stimulation.

Jiazhi Chen, Jens Volkmann, Chi Wang Ip

Erratum issuedAbstract readReview
In one paragraph

Review in NPJ Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jiazhi ChenDepartment of Neurology, University Hospital of Würzburg, Josef-Schneider-Straße 11, Würzburg, Germany.
Jens VolkmannDepartment of Neurology, University Hospital of Würzburg, Josef-Schneider-Straße 11, Würzburg, Germany.ORCID http://orcid.org/0000-0002-9570-593X
Chi Wang IpDepartment of Neurology, University Hospital of Würzburg, Josef-Schneider-Straße 11, Würzburg, Germany. ip_c@ukw.de.ORCID http://orcid.org/0000-0003-0484-385X

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) Project-ID 424778381-TRR 295Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg (Interdisciplinary Center for Clinical Research, University Hospital of Würzburg) S-506, N-362
6 · The paper itself

Abstract

Deep brain stimulation (DBS) is an established treatment for motor disorders like Parkinson's disease, but its mechanisms and effects on neurons and networks are not fully understood, limiting research-driven progress. This review presents a framework that combines neurophysiological insights and translational research to enhance DBS therapy, emphasizing biomarkers, device technology, and symptom-specific neuromodulation. It also examines the role of animal research in improving DBS, while acknowledging challenges in clinical translation.

Identifiers

PMID39516465
PMCPMC11549317

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.