ArticleNature communications2024
Molecular signatures of cortical expansion in the human foetal brain.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Motifs of brain cortical folding from birth to adulthood.Nature communications · 2026Article
- Fetal Cortical Layers and Midline Histological Alterations in the BTBR Mouse Model of Neurodevelopmental Disorders.Biology · 2026Article
- A Mechanical Theory for the Formation of Short Association Fibers in the Brain.bioRxiv : the preprint server for biology · 2026Article
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Nature communications · 2026Article
- Mapping the genetic architecture of human cortical expansion and its links to neuropsychiatric disorders.bioRxiv : the preprint server for biology · 2026Article
- Prenatal cannabis use is associated with altered miRNA and protein expression in the developing human brain.Journal of psychopharmacology (Oxford, England) · 2026Article
- Aberrant chromatin remodeling influences human neural cell fate change in Trisomy 21.bioRxiv : the preprint server for biology · 2026Article
- Genetic insights on the mechanisms of human cortical folding.bioRxiv : the preprint server for biology · 2026Article
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Research square · 2026Article
- Functional KCC2 expression marks an evolutionarily conserved population of early-maturing interneurons in the perinatal cortex.Nature communications · 2025Article
- Transcriptomic divergence of network hubs in the prenatal human brain.Communications biology · 2025Article
- Maternal oxidative stress throughout pregnancy and early childhood neurodevelopment at different stages: insights from a prospective cohort study.BMC medicine · 2025Article
- Stress landscape of folding brain serves as a map for axonal pathfinding.Nature communications · 2025Article
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13 authors.
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Abstract
The third trimester of human gestation is characterised by rapid increases in brain volume and cortical surface area. Recent studies have revealed a remarkable molecular diversity across the prenatal cortex but little is known about how this diversity translates into the differential rates of cortical expansion observed during gestation. We present a digital resource, μBrain, to facilitate knowledge translation between molecular and anatomical descriptions of the prenatal brain. Using μBrain, we evaluate the molecular signatures of preferentially-expanded cortical regions, quantified in utero using magnetic resonance imaging. Our findings demonstrate a spatial coupling between areal differences in the timing of neurogenesis and rates of neocortical expansion during gestation. We identify genes, upregulated from mid-gestation, that are highly expressed in rapidly expanding neocortex and implicated in genetic disorders with cognitive sequelae. The μBrain atlas provides a tool to comprehensively map early brain development across domains, model systems and resolution scales.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.