Evidence map›Paper›PMID 39516459›Full record

ArticleCell death & disease2024

TAp73 regulates mitochondrial dynamics and multiciliated cell homeostasis through an OPA1 axis.

Niall A Buckley, Andrew Craxton, Xiao-Ming Sun, Emanuele Panatta, Lucia Giraldez Pinon, Sina Beier, Lajos Kalmar, Jaime Llodrá, Nobuhiro Morone, Ivano Amelio and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Niall A BuckleyMRC Toxicology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0003-3676-0741
Andrew CraxtonMRC Toxicology Unit, University of Cambridge, Cambridge, UK.
Xiao-Ming SunMRC Toxicology Unit, University of Cambridge, Cambridge, UK.
Emanuele PanattaMRC Toxicology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0001-8723-9564
Lucia Giraldez PinonMRC Toxicology Unit, University of Cambridge, Cambridge, UK.
Sina BeierMRC Toxicology Unit, University of Cambridge, Cambridge, UK.
Lajos KalmarMRC Toxicology Unit, University of Cambridge, Cambridge, UK.
Jaime LlodráMRC Toxicology Unit, University of Cambridge, Cambridge, UK.
Nobuhiro MoroneMRC Toxicology Unit, University of Cambridge, Cambridge, UK.
Ivano AmelioMRC Toxicology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0002-9126-5391
Gerry MelinoMRC Toxicology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9428-5972
L Miguel MartinsMRC Toxicology Unit, University of Cambridge, Cambridge, UK. lm795@cam.ac.uk.
Marion MacFarlaneMRC Toxicology Unit, University of Cambridge, Cambridge, UK. mm2312@mrc-tox.cam.ac.uk.ORCID 0000-0001-7886-1159

Funding

RCUK | Medical Research Council (MRC) MC_UU_00025/2 (RG94521)RCUK | Medical Research Council (MRC) MC_UU_00025/3 (RG94521)RCUK | Medical Research Council (MRC) MC_UU_00025/4 (RG94521)RCUK | Medical Research Council (MRC) RG94521
6 · The paper itself

Abstract

Dysregulated mitochondrial fusion and fission has been implicated in the pathogenesis of numerous diseases. We have identified a novel function of the p53 family protein TAp73 in regulating mitochondrial dynamics. TAp73 regulates the expression of Optic Atrophy 1 (OPA1), a protein responsible for controlling mitochondrial fusion, cristae biogenesis and electron transport chain function. Disruption of this axis results in a fragmented mitochondrial network and an impaired capacity for energy production via oxidative phosphorylation. Owing to the role of OPA1 in modulating cytochrome c release, TAp73

Indexed as

GTP PhosphohydrolasesHomeostasisMice, KnockoutMitochondrial DynamicsTumor Protein p73AnimalsApoptosisCell DifferentiationCiliaHumansMiceMitochondriaPulmonary Disease, Chronic ObstructiveGTP PhosphohydrolasesOPA1 protein, humanOpa1 protein, mouseTP73 protein, humanTumor Protein p73

Identifiers

PMID39516459
PMCPMC11549358

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.