Evidence map›Paper›PMID 39516425›Full record

ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Neurological, psychological, psychosocial complications of long-COVID and their management.

Sareesh Naduvil Narayanan, Sreeshma Padiyath, Krishnapriya Chandrababu, Lima Raj, Baby Chakrapani P S, George Abraham Ninan, Ajith Sivadasan, Alexander Ryan Jacobs, Yan Wa Li, Anand Bhaskar

Abstract readReview
In one paragraph

Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Observational
  7. A pain from the nose to the head: neurological commitment during long COVID.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sareesh Naduvil NarayananDepartment of Physiology, School of Medicine and Dentistry, AUC-UK Track, University of Central Lancashire, Preston, UK. sareeshnn@yahoo.co.in.ORCID http://orcid.org/0000-0002-2980-2352
Sreeshma PadiyathDepartment of Microbiology, School of Medicine and Dentistry, AUC-UK Track, University of Central Lancashire, Preston, UK.
Krishnapriya ChandrababuCentre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology (CUSAT), Kochi, India.
Lima RajDepartment of Psychology, Sree Sankaracharya University of Sanskrit, Kalady, India.
Baby Chakrapani P SCentre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology (CUSAT), Kochi, India.
George Abraham NinanDepartment of Neurology, Christian Medical College (CMC), Vellore, India.
Ajith SivadasanDepartment of Neurology, Christian Medical College (CMC), Vellore, India.
Alexander Ryan JacobsSchool of Medicine and Dentistry, AUC-UK Track, University of Central Lancashire, Preston, UK.
Yan Wa LiFaculty of Medicine, Macau University of Science and Technology, Macau, China.
Anand BhaskarDepartment of Physiology, Christian Medical College (CMC), Vellore, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since it first appeared, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has had a significant and lasting negative impact on the health and economies of millions of individuals all over the globe. At the level of individual health too, many patients are not recovering fully and experiencing a long-term condition now commonly termed 'long-COVID'. Long-COVID is a collection of symptoms which must last more than 12 weeks following initial COVID infection, and which cannot be adequately explained by alternate diagnoses. The neurological and psychosocial impact of long-COVID is itself now a global health crisis and therefore preventing, diagnosing, and managing these patients is of paramount importance. This review focuses primarily on: neurological functioning deficits; mental health impacts; long-term mood problems; and associated psychosocial issues, among patients suffering from long-COVID with an eye towards the neurological basis of these symptoms. A concise account of the clinical relevance of the neurological and psychosocial impacts of long-COVID, the effects on long-term morbidity, and varied approaches in managing patients with significant chronic neurological symptoms and conditions was extracted from the literature, analysed and reported. A comprehensive account of plausible pathophysiological mechanisms involved in the development of long-COVID, its management, and future research needs have been discussed.

Indexed as

COVID-19Nervous System DiseasesPost-Acute COVID-19 SyndromeHumansMental DisordersSARS-CoV-2AnxietyCOVID-19Cytokine stormLong-COVIDMemory impairmentNeurodegenerationSleep disturbance

Identifiers

PMID39516425
PMCPMC11698801

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.