Evidence map›Paper›PMID 39516403›Full record

ArticleSurgery today2025

Role of intermediate water in alleviating postsurgical intrapericardial adhesion.

Tatsuya Suzuki, Hayato Konishi, Akiyo Suzuki, Takahiro Katsumata, Yasuhiro Fukuda, Koki Miyamoto, Tomokazu Ise, Yukiko Tanaka, Aki Yamamoto, Panyue Wen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgery today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tatsuya Suzuki
Hayato Konishi
Akiyo Suzuki
Takahiro Katsumata
Yasuhiro FukudaResearch and Development Center, The Japan Wool Textile Co., Ltd, Kakogawa, 440 Funamoto, Yoneda-cho, Hyogo, 675-0053, Japan.
Koki MiyamotoResearch and Development Center, The Japan Wool Textile Co., Ltd, Kakogawa, 440 Funamoto, Yoneda-cho, Hyogo, 675-0053, Japan.
Tomokazu IseResearch and Development Center, The Japan Wool Textile Co., Ltd, Kakogawa, 440 Funamoto, Yoneda-cho, Hyogo, 675-0053, Japan.
Yukiko TanakaSoft Materials Chemistry, Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Aki YamamotoSoft Materials Chemistry, Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Panyue WenSoft Materials Chemistry, Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Shohei ShiomotoSoft Materials Chemistry, Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Masaru TanakaSoft Materials Chemistry, Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Shintaro NemotoDepartment of Thoracic and Cardiovascular Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-0801, Japan. snemoto@ompu.ac.jp.ORCID http://orcid.org/0000-0001-6995-9760

Funding

Ministry of Education, Culture, Sports, Science and Technology a Grant-in-Aid for Scientific Research on Innovati
6 · The paper itself

Abstract

purposeVarious polymers have been used as postsurgical antiadhesive materials; however, the mechanisms underlying their efficacy remain unclear. Intermediate water has been found to prevent the adhesion between polymer molecules and proteins or cells. The present study investigated the role of intermediate water retained in the polymer in alleviating postsurgical pericardial adhesion.

methodsHydrophobic fabrics were prepared using biodegradable polyglycolic acid. To add intermediate water, the fabric fibers were coated with poly(oxyethylene)oleyl ethers. Intermediate water in the hydrated state was detected by a thermal analysis for each material, and cell attachment to the fibers with or without coating was observed in vitro. Using a canine model of postsurgical pericardial adhesion, the severity of adhesion was examined along with a histological assessment during treatment, with or without fabric coating.

resultsIntermediate water was detected in the coating materials but not in polyglycolic acid. Coating significantly reduced the cell attachment to the fibers. Coating also alleviated adhesion by reducing inflammation in the fibrous layer and replacing the fabric and granulomas that develop around the surgical sutures in the pericardial space.

conclusionsIntermediate water in the hydrated polymer of anti-adhesives may play an important role in alleviating postoperative pericardial adhesion.

Indexed as

PericardiumPostoperative ComplicationsWaterAnimalsCell AdhesionDisease Models, AnimalDogsHydrophobic and Hydrophilic InteractionsPolyglycolic AcidPolymersTissue AdhesionsPolyglycolic AcidPolymersWaterAntiadhesiveCardiac surgeryIntermediate waterPolymerPostoperative pericardial adhesion

Identifiers

PMID39516403
PMCPMC12098447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.