Evidence map›Paper›PMID 39516372›Full record

ArticleLeukemia2025

The effect of methylation on the let-7-BCL2L1-BCL2 axis and the potential use of hypomethylating and BH3 mimetic drugs in histiocytic neoplasms.

Mali Salmon-Divon, Refael Meyuchas, Ofer Shpilberg, Elimelech Okon, Jamal Benhamida, Mariko Yabe, Kseniya Petrova-Drus, Tal Zvida-Bloch, May Basood, Roei Mazor and 5 more

Abstract read
In one paragraph

Article in Leukemia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mali Salmon-Divon *Department of Molecular Biology, Faculty of Natural Sciences, Ariel University, Ariel, Israel.
Refael Meyuchas *Department of Molecular Biology, Faculty of Natural Sciences, Ariel University, Ariel, Israel.ORCID http://orcid.org/0009-0007-6744-1969
Ofer ShpilbergAdelson School of Medicine, Ariel University, Ariel, Israel.
Elimelech OkonFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Jamal BenhamidaDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mariko YabeDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kseniya Petrova-DrusDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tal Zvida-BlochDepartment of Molecular Biology, Faculty of Natural Sciences, Ariel University, Ariel, Israel.
May BasoodClinic of Histiocytic Neoplasms, Institute of Hematology, Assuta Medical Center, Tel-Aviv, Israel.
Roei MazorClinic of Histiocytic Neoplasms, Institute of Hematology, Assuta Medical Center, Tel-Aviv, Israel.
Benjamin H DurhamMolecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Julien HarocheService de Médecine Interne, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Sorbonne Université, Faculté de Médecine, Paris, France.
Omar Abdel-WahabMolecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Eli L Diamond *Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. diamone1@mskcc.org.ORCID http://orcid.org/0000-0001-5456-5961
Oshrat Hershkovitz-Rokah *Department of Molecular Biology, Faculty of Natural Sciences, Ariel University, Ariel, Israel. oshratr@assuta.co.il.ORCID http://orcid.org/0000-0003-4685-0679

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Genetic and molecular basis for SRSF2 mutations in myelodysplasiaR01HL128239 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Omar Abdel-Wahab, Robert K Bradley · 2015 to 2026
$8.0M
Molecular Pathogenesis and Therapy of Systemic Histiocytic NeoplasmsR37CA259260 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Eli Lous Diamond · 2021 to 2026
$3.3M
Synthetic introns for selective targeting of RNA splicing factor-mutant leukemiaR01CA283364 · NCI · FRED HUTCHINSON CANCER CENTER · PI Omar Abdel-Wahab, Robert K Bradley · 2023 to 2026
$2.9M
Targeting an RNA Binding Protein Network in Acute Myeloid LeukemiaR01CA242020 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ABDEL-WAHAB, OMAR, AIFANTIS, IANNIS · 2020 to 2024
$2.7M
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) HL128239NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA242020NCI NIH HHS R01 CA283364NCI NIH HHS R37 CA259260NHLBI NIH HHS R01 HL128239
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39516372
PMCPMC11794134

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.