Evidence map›Paper›PMID 39516316›Full record

ArticleBJC reports2024

The association between being breastfed in infancy and risks of cancer in adulthood-a UK Biobank study.

Dan Hameiri-Bowen, Dorthe C Pedersen, Britt W Jensen, Julie Aarestrup, Kathleen M Rasmussen, Jennifer L Baker, Lise G Bjerregaard

Abstract read
In one paragraph

Article in BJC reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dan Hameiri-BowenCenter for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark. dan.hameiri-bowen@regionh.dk.ORCID http://orcid.org/0000-0003-1592-6028
Dorthe C PedersenCenter for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2227-323X
Britt W JensenCenter for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4921-9604
Julie AarestrupCenter for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2258-2120
Kathleen M RasmussenDivision of Nutritional Sciences, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0003-2111-6478
Jennifer L BakerCenter for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-9649-6615
Lise G BjerregaardCenter for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8471-0832

Funding

Novo Nordisk Fonden NNF21OC0071349
6 · The paper itself

Abstract

backgroundBeing breastfed has established benefits for infant health, but its long-term effects on adult diseases, including cancer, remain underexplored. We examined associations between being breastfed in infancy and the risks of common cancers.

methodsData from 339,115 participants (191,117 women) enrolled in the UK Biobank with self-reported breastfeeding data were linked to national cancer registries. Cox models estimated sex-specific hazard ratios (HR) and 95% confidence intervals (CI) for the associations between being breastfed (ever/never) and risks of overall cancer as well as common cancer sites.

resultsIn total, 34,392 incident cancers (17,895 in women) were registered. The HR of overall cancer associated with being breastfed was 1.05 (95% CI 1.01-1.09) in women and 1.00 (95% CI 0.96-1-04) in men. In site-specific analysis being breastfed was associated with an increased risk of breast and ovarian cancer in women and a reduced risk of oesophageal cancer in men. DISCUSSION: We found that having been breastfed was associated with a marginally increased risk of adult cancer in women, but we found no evidence of an association in men. These findings should be viewed within the study limitations, and do not outweigh the many benefits that breastfeeding provides.

Identifiers

PMID39516316
PMCPMC11523963

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.