Evidence map›Paper›PMID 39516242›Full record

ArticleCommunications chemistry2024

Rotaxanes with a photoresponsive macrocycle modulate the lipid bilayers of large and giant unilamellar vesicles.

Udyogi N K Conthagamage, Rajitha Rajeshwar T, Stijn van der Ham, Nasim Akhtar, Macallister L Davis, Senuri G Jayawardana, Lilia Lopez, Hanumantha Rao Vutukuri, Jeremy C Smith, Micholas Dean Smith and 1 more

Abstract read
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In one paragraph

Article in Communications chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Let There be Light! Light as an Engine and Regulator in Synthetic Cells.Angewandte Chemie (International ed. in English) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Udyogi N K ConthagamageDepartment of Chemistry, Louisiana State University, Baton Rouge, LA, USA.
Rajitha Rajeshwar TUT/ORNL Center for Molecular Biophysics, Oak Ridge, TN, USA.
Stijn van der HamActive Soft Matter and Bio-inspired Materials Lab, Faculty of Science and Technology, MESA+ Institute, University of Twente, Enschede, Overijssel, The Netherlands.ORCID http://orcid.org/0009-0005-6765-1275
Nasim AkhtarDepartment of Chemistry, Louisiana State University, Baton Rouge, LA, USA.
Macallister L DavisDepartment of Chemistry, Louisiana State University, Baton Rouge, LA, USA.
Senuri G JayawardanaDepartment of Chemistry, Louisiana State University, Baton Rouge, LA, USA.
Lilia LopezDepartment of Chemistry, Louisiana State University, Baton Rouge, LA, USA.ORCID http://orcid.org/0009-0004-4036-5423
Hanumantha Rao VutukuriActive Soft Matter and Bio-inspired Materials Lab, Faculty of Science and Technology, MESA+ Institute, University of Twente, Enschede, Overijssel, The Netherlands.ORCID http://orcid.org/0000-0001-6255-2298
Jeremy C SmithUT/ORNL Center for Molecular Biophysics, Oak Ridge, TN, USA. smithjc@ornl.gov.
Micholas Dean SmithUT/ORNL Center for Molecular Biophysics, Oak Ridge, TN, USA. msmit316@utk.edu.ORCID http://orcid.org/0000-0002-0777-7539
Víctor García-LópezDepartment of Chemistry, Louisiana State University, Baton Rouge, LA, USA. vglopez@lsu.edu.ORCID http://orcid.org/0000-0003-2915-4591

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rotaxanes equipped with actuators hold great potential for developing highly functional molecular machines. Such systems could significantly enhance our ability to study and manipulate biological and artificial membranes. Here, we introduce a rotaxane with a ring featuring two azobenzene photoswitches, which retain their photoreversibility and can be stochastically shuttled along the axle in solution. Studies in model bilayers, supported by molecular dynamics simulations, show how azobenzene photoswitching alters the interaction of rotaxanes with surrounding lipids, leading to changes in lipid packing. Such changes in the lipid bilayer were leveraged to induce the light-triggered release of sulforhodamine B from large unilamellar vesicles. Additionally, light activation of the rotaxanes is shown to induce reversible contraction and expansion of giant unilamellar vesicles. The results provide novel insights into the interactions and operation of rotaxanes in lipid bilayers and their impact on membrane properties. This will aid in developing systems for precise membrane manipulation for applications in biomedicine and bioengineering.

Identifiers

PMID39516242
PMCPMC11549230

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.