Evidence map›Paper›PMID 39515857›Full record

ArticleBMJ open2024

Traditional, complementary and integrative medicine therapies for the treatment of mild/moderate acute COVID-19: protocol for a systematic review and network meta-analysis.

Anqi Li, Gordon Guyatt, Derek Chu, Lehana Thabane, Jason W Busse, Behnam Sadeghirad, Qingyong He, Long Ge, Qiukui Hao, Sunita Vohra and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Anqi LiGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-0262-9008
Gordon GuyattDepartment of Health Research Methods, Evidence and Impact, Mcmaster University, Hamilton, Ontario, Canada.
Derek ChuDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Lehana ThabaneDepartment of Health Research Methods, Evidence and Impact, Mcmaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0003-0355-9734
Jason W BusseDepartment of Health Research Methods, Evidence and Impact, Mcmaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-0178-8712
Behnam SadeghiradDepartment of Health Research Methods, Evidence and Impact, Mcmaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0001-9422-5232
Qingyong HeGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Long GeEvidence-Based Social Sciences Research Centre, School of Public Health, Lanzhou University, Lanzhou, Gansu, China.ORCID http://orcid.org/0000-0002-3555-1107
Qiukui HaoSchool of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-5160-5144
Sunita VohraPediatrics, University of Alberta, Edmonton, Alberta, Canada.
Benno BrinkhausInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Claudia M WittInstitute for Complementary and Integrative Medicine, University Hospital Zurich, Zurich, Zürich, Switzerland.
Yachan LiIntegrated Health Service Department, World Health Organization, Geneva, Switzerland.
Geetha KrishnanWorld Health Organization, Geneva, Switzerland.
Thomas AgoritsasDepartment of Health Research Methods, Evidence and Impact, Hamilton, Stockholm, ON, Sweden.
Lisa Susan WielandUniversity of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID http://orcid.org/0000-0003-2157-0603
Sarika ChaturvediDepartment of Public Health and Environment, R D Gardi Medical College, Ujjain, MP, India.
Kavita U KothariWorld Health Organization, Geneva, Switzerland.
Bhushan PatwardhanDr D Y Patil Vidyapeeth, Pune, Maharashtra, India.ORCID http://orcid.org/0000-0003-3918-2609
Min FangDepartment of Tuina, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID http://orcid.org/0000-0001-5241-6460
Lingjun KongInstitute of Tuina, Shanghai Institute of Traditional Chinese Medicine, Shanghai, China.ORCID http://orcid.org/0000-0002-6854-4202
Jun RenDepartment of Tuina, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Myeong Soo LeeKorea Institute of Oriental Medicine, Daejeon, Dajeon, Korea (the Republic of).ORCID http://orcid.org/0000-0001-6651-7641
Angela CheungInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
Patrick M OkwenEffective Basic Services (eBASE) Africa, Bamenda, Cameroon.
Bernice DowneyMcMaster University, Hamilton, Ontario, Canada.
Lin AngClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Korea (the Republic of).ORCID http://orcid.org/0000-0002-7273-9600
Jialing ZhuGuangzhou University of Chinese Medicine, Guangzhou, China.
Yuqing ZhangDepartment of Health Research Methods, Evidence and Impact, Mcmaster University, Hamilton, Ontario, Canada madisonz1220@gmail.com.ORCID http://orcid.org/0000-0002-6318-3575

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundIncreasing evidence has emerged for traditional, complementary and integrative medicine (TCIM) to treat COVID-19 which requires systematic summaries of the net benefits of interventions against standard care and one another. The study aims to conduct a systematic review and network meta-analysis (NMA) regarding TCIM therapies for treating mild/moderate acute COVID-19, potentially informing the WHO guideline development and clinical decision-making. METHODS AND ANALYSIS: We will search Embase, MEDLINE, Virtual Health Library on Traditional Complementary and Integrative Medicine, Cochrane Central Register of Controlled Trials, WHO's International Clinical Trials Registry Platform with additional searches of Chinese and Korean literature sources for randomised controlled trials comparing TCIM with placebo, standard care, no treatment or with an alternate type of TCIM to treat COVID-19. We will limit the search dates from 2020 to 28 March 2024. Reviewers will, in duplicate, screen eligible articles, extract data and evaluate the risk of bias. We will conduct frequentist network meta-analyses for network comparisons and each outcome. We will assess the certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation approach and classify interventions from most to least effective or harmful. ETHICS AND DISSEMINATION: This NMA is based on the existing trials and data which is not subject to ethical approval. We will publish the NMA in a peer-reviewed journal. This may provide methodological reference and clinical evidence for TCIM on future epidemic-prone diseases. PROSPERO REGISTRATION NUMBER: CRD42024517321.

Indexed as

Complementary TherapiesCOVID-19Integrative MedicineHumansNetwork Meta-Analysis as TopicPandemicsResearch DesignSARS-CoV-2Systematic Reviews as TopicComplementary MedicineCOVID-19Network Meta-AnalysisProtocols & guidelines

Identifiers

PMID39515857
PMCPMC11552603

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.