Evidence map›Paper›PMID 39515332›Full record

ArticleCell reports methods2024

WEST is an ensemble method for spatial transcriptomics analysis.

Jiazhang Cai, Huimin Cheng, Shushan Wu, Wenxuan Zhong, Guo-Cheng Yuan, Ping Ma

Abstract read
In one paragraph

Article in Cell reports methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. JADE: Joint Alignment and Deep Embedding for Multi-Slice Spatial Transcriptomics.Advances in neural information processing systems · 2025
    Article
  5. Computer Vision Methods for Spatial Transcriptomics: A Survey.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiazhang CaiDepartment of Statistics, University of Georgia, 310 Herty Drive, Athens, GA 30602, USA.
Huimin ChengDepartment of Biostatistics, Boston University, 801 Massachusetts Avenue, Crosstown Center, Boston, MA 02118, USA.
Shushan WuDepartment of Statistics, University of Georgia, 310 Herty Drive, Athens, GA 30602, USA.
Wenxuan ZhongDepartment of Statistics, University of Georgia, 310 Herty Drive, Athens, GA 30602, USA. Electronic address: wenxuan@uga.edu.
Guo-Cheng YuanDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, NY 10029, USA. Electronic address: guo-cheng.yuan@mssm.edu.
Ping MaDepartment of Statistics, University of Georgia, 310 Herty Drive, Athens, GA 30602, USA. Electronic address: pingma@uga.edu.

Funding

Collaborative Research: DMS/NIGMS 2: Novel machine-learning framework for AFMscanner in DNA-protein interaction detectionR01GM152814 · NIGMS · UNIVERSITY OF GEORGIA · PI Wenxuan Zhong · 2023 to 2026
$1.2M
NIGMS NIH HHS R01 GM152814
6 · The paper itself

Abstract

Spatial transcriptomics is a groundbreaking technology, enabling simultaneous profiling of gene expression and spatial orientation within biological tissues. Yet when analyzing spatial transcriptomics data, effective integration of expression and spatial information poses considerable analytical challenges. Although many methods have been developed to address this issue, many are platform specific and lack the general applicability to analyze diverse datasets. In this article, we propose a method called the weighted ensemble method for spatial transcriptomics (WEST) that utilizes ensemble techniques to improve the performance and robustness of spatial transcriptomics data analytics. We compare the performance of WEST with six methods on both synthetic and real-world datasets. WEST represents a significant advance in detecting spatial domains, offering improved accuracy and flexibility compared to existing methods, making it a valuable tool for spatial transcriptomics data analytics.

Indexed as

Gene Expression ProfilingTranscriptomeAlgorithmsComputational BiologyHumansSpatial AnalysisCP: systems biologydeep learningensemble learningseqFISHspatial domain identificationspatial transcriptomicsVisium

Identifiers

PMID39515332
PMCPMC11705770

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.