Evidence map›Paper›PMID 39514937›Full record

ArticlePsychiatry research2024

Exploring psychotic symptoms among substance-naïve individuals and recent abstainers without a psychosis diagnosis: A cross-country study across Kenya, Uganda, Ethiopia, and South Africa.

Isaac Babu Kisiang'ani, Mohammed Aden, Henry R Mwangi, Dickens Akena, Melkam Alemayehu, Julius Barasa, Bizu Gelaye, Stella Gichuru, Symon M Kariuki, Edith Kamaru Kwobah and 11 more

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Article in Psychiatry research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

21 authors.

Isaac Babu Kisiang'aniDepartment of Mental Health, Bungoma County Referral Hospital, Kenya; Department of Mental Health and Behavioural Sciences Moi University, Eldoret, Kenya. Electronic address: drbabu88@gmail.com.
Mohammed AdenDepartment of Mental Health and Behavioural Sciences Moi University, Eldoret, Kenya; Department of Mental Health, Wajir County Referral Hospital, Garissa, Kenya.
Henry R MwangiDepartment of Health Information Management, Moi Teaching and Referral Hospital, Eldoret, Kenya.
Dickens AkenaDepartment of Psychiatry, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
Melkam AlemayehuDepartment of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Julius BarasaAcademic Model Providing Access to Health Care, Eldoret, Kenya.
Bizu GelayeDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Psychiatry, Harvard Medical School and The Chester M. Pierce MD, Division of Global Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Stella GichuruDepartment of Medicine, Medical College East Africa, The Aga Khan University, Nairobi, Kenya; Academic Model Providing Access to Health Care, Eldoret, Kenya.
Symon M KariukiNeurosciences Unit, Clinical Department, KEMRI-Wellcome Trust Research Programme-Coast, Kilifi, Kenya; Department of Psychiatry, University of Oxford, Oxford, UK.
Edith Kamaru KwobahDepartment of Mental Health, Moi Teaching and Referral Hospital, Eldoret, Kenya.
Joseph KyebuzibwaDepartment of Psychiatry, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
Rehema M MwemaNeurosciences Unit, Clinical Department, KEMRI-Wellcome Trust Research Programme-Coast, Kilifi, Kenya.
Charles R J C NewtonNeurosciences Unit, Clinical Department, KEMRI-Wellcome Trust Research Programme-Coast, Kilifi, Kenya; Department of Psychiatry, University of Oxford, Oxford, UK.
Linnet OngeriCentre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya.
Adele PretoriusDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Dan J SteinDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; SA MRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town and Neuroscience Institute, Cape Town, South Africa.
Anne StevensonDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Rocky E StroudDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Solomon TeferraDepartment of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Zukiswa ZingelaExecutive Dean's Office, Faculty of Health Sciences, Nelson Mandela University, Gqeberha, South Africa.
Lukoye AtwoliDepartment of Mental Health and Behavioural Sciences Moi University, Eldoret, Kenya; Brain and Mind Institute, The Aga Khan University, Nairobi, Kenya; Department of Medicine, Medical College East Africa, The Aga Khan University, Nairobi, Kenya.

Funding

1/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African AncestriesU01MH125047 · NIMH · BROAD INSTITUTE, INC. · PI MARTIN, ALICIA, NEALE, BENJAMIN MICHAEL · 2020 to 2024
$11.5M
2/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African AncestriesU01MH125045 · NIMH · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI KOENEN, KARESTAN C · 2020 to 2024
$3.1M
Psychosis Genetics Research in Africa: Building Capacity by Investing in PeopleR01MH120642 · NIMH · BROAD INSTITUTE, INC. · PI AKENA, DICKENS HOWARD, CHIBNIK, LORI BETH · 2019 to 2023
$3.1M
NIMH NIH HHS R01 MH120642NIMH NIH HHS U01 MH125045NIMH NIH HHS U01 MH125047Wellcome Trust
6 · The paper itself

Abstract

Psychotic symptoms are of increasing interest in mental health due to their predictive value for future psychotic disorders. While these symptoms are prevalent in the general population, their occurrence varies globally. This study aimed to explore the prevalence and factors associated with psychotic symptoms among individuals identified as substance-naïve and recent abstainers without a history of psychosis. A cross-sectional analysis was conducted on 11,686 participants who reported no lifetime substance use, no substance use in the previous three months, and did not have a diagnosis of psychosis. The study utilized the Psychosis Screening Questionnaire to estimate the one-year prevalence of psychotic symptoms and their associations with demographic and clinical attributes. Results revealed a 3.5 % overall prevalence of psychotic symptoms with 2.9 % prevalence among substance naïve and 4.3 % among recent abstainers. Factors associated with psychotic symptoms were age, being female, having chronic medical conditions, encountering traumatic life events being divorced or separated and lower education levels which positively correlated with symptom scores. There is a need for future investigations and longitudinal studies to uncover the underlying mechanisms and impacts of psychotic symptoms.

Indexed as

Psychotic DisordersAdolescentAdultCross-Sectional StudiesEthiopiaFemaleHumansKenyaMaleMiddle AgedPrevalenceSouth AfricaUgandaYoung AdultCurrent substance usersPSQ, Psychosis, AfricaRecent abstainers

Identifiers

PMID39514937
PMCPMC12529505

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.