Evidence map›Paper›PMID 39514919›Full record

ArticleArchives of oral biology2025

Ameloblastin binding to biomimetic models of cell membranes - A continuum of intrinsic disorder.

Garry W Buchko, Natalie C Kegulian, Janet Moradian-Oldak

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Article in Archives of oral biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Garry W BuchkoEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99352, USA; School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA. Electronic address: garry.buchko@pnnl.gov.
Natalie C KegulianCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA.
Janet Moradian-OldakCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA; Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: joldak@usc.edu.

Funding

MATRIX-BASED MINERAL (MBM) ENAMEL BIOMIMETICSR01DE013414 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Janet Oldak · 2001 to 2026
$8.6M
Structural, spatial, and temporal features guiding amelogenins transformation of calcium phosphate into enamelR01DE015347 · NIDCR · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI SHAW, WENDY J · 2005 to 2025
$8.2M
MATRIX BASED MINERAL ENAMEL-BIOMIMETICSR56DE013414 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OLDAK, JANET · 2018 to 2018
$387k
NIDCR NIH HHS R01 DE013414NIDCR NIH HHS R01 DE015347NIDCR NIH HHS R56 DE013414
6 · The paper itself

Abstract

objectiveA 37-residue amino acid sequence corresponding to the segment encoded by exon-5 of murine ameloblastin (Ambn), AB2 (Y67-Q103), has been implicated with membrane association, ameloblastin self-assembly, and amelogenin-binding. Our aim was to characterize, at the residue level, the structural behavior of AB2 bound to chemical mimics of biological membranes using NMR spectroscopy.

designTo better define the structure of AB2 using NMR-based methods, recombinant

resultsAmide chemical shift and intensity perturbations observed in

conclusionsA continuum of intrinsic disorder in the membrane-bound state may be responsible for ameloblastin's ability to dynamically interact with multiple partners at the same site during amelogenesis.

Indexed as

Cell MembraneDental Enamel ProteinsMicellesAmino Acid SequenceAnimalsBiomimeticsMagnetic Resonance SpectroscopyMiceNuclear Magnetic Resonance, BiomolecularProtein BindingAmbn protein, mouseDental Enamel ProteinsMicellesAmeloblastinAmelogenesisBiomineralizationEnamel formationLipidsTransient structure

Identifiers

PMID39514919
PMCPMC12165007

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.