Evidence map›Paper›PMID 39514831›Full record

ArticleAmerican journal of respiratory and critical care medicine2025

Unsupervised Classification of the Host Response Identifies Dominant Pathobiological Signatures of Sepsis in Sub-Saharan Africa.

Matthew J Cummings, Julius J Lutwama, Nicholas Owor, Alin S Tomoiaga, Jesse E Ross, Moses Muwanga, Christopher Nsereko, Irene Nayiga, Stephen Kyebambe, Joseph Shinyale and 21 more

Abstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Observational
  2. Observational
  3. Article
  4. Review
  5. Observational
  6. HIV, Sepsis, and Postdischarge Mortality in Sub-Saharan Africa.American journal of respiratory and critical care medicine · 2025
    Article
  7. Reply to Al-WardAmerican journal of respiratory and critical care medicine · 2025
    Article
  8. Decoding Sepsis Globally: Toward Precision Medicine through Clustering in Sub-Saharan Africa.American journal of respiratory and critical care medicine · 2025
    Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Matthew J CummingsDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Julius J LutwamaDepartment of Arbovirology, Emerging and Re-emerging Infectious Diseases, and.
Nicholas OworDepartment of Arbovirology, Emerging and Re-emerging Infectious Diseases, and.
Alin S TomoiagaDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Jesse E RossDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Moses MuwangaEntebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda.
Christopher NserekoEntebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda.
Irene NayigaEntebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda.
Stephen KyebambeEntebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda.
Joseph ShinyaleEntebbe Regional Referral Hospital, Ministry of Health, Entebbe, Uganda.
Thomas OcharTororo General Hospital, Ministry of Health, Tororo, Uganda.
Moses KiwubeyiTororo General Hospital, Ministry of Health, Tororo, Uganda.
Rittah NankwangaTororo General Hospital, Ministry of Health, Tororo, Uganda.
Kai NieHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York.
Hui XieHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York.
Sam Miake-LyeHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York.
Bryan VillagomezHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York.
Jingjing QiHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York.
Steven J ReynoldsDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Martina Cathy NakibuukaRakai Health Sciences Program, Kalisizo, Uganda; and.
Xuan LuDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
John KayiwaDepartment of Arbovirology, Emerging and Re-emerging Infectious Diseases, and.
Mercy HaumbaDepartment of Arbovirology, Emerging and Re-emerging Infectious Diseases, and.
Joweria NakaseeguDepartment of Arbovirology, Emerging and Re-emerging Infectious Diseases, and.
Xiaoyu CheCenter for Infection and Immunity.
Misaki WayengeraDepartment of Immunology and Molecular Biology, College of Health Sciences, Makerere University, Kampala, Uganda.
Sankar GhoshDepartment of Microbiology and Immunology, and.
Seunghee Kim-SchulzeHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York.
W Ian LipkinDepartment of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons.
Barnabas BakamutumahoDepartment of Arbovirology, Emerging and Re-emerging Infectious Diseases, and.
Max R O'DonnellDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
The Columbia University Training Program in Lung ScienceT32HL105323 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jahar Bhattacharya, Wellington V. Cardoso · 2011 to 2026
$4.7M
TB and Other Pulmonary Complications of AIDS Research Training ProgramD43TW009607 · FIC · YALE UNIVERSITY · PI DAVIS, JOHN LUCIAN, KATAMBA, ACHILLES · 2013 to 2022
$3.2M
Subtyping sepsis in Uganda using clinical, pathogen, and host response profilingK23AI163364 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CUMMINGS, MATTHEW JOHN · 2022 to 2025
$733k
Burroughs Wellcome FundFIC NIH HHS D43 TW009607FIC NIH HHS D43TW009607National Institute of Allergy and Infectious Diseases K23AI163364NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1TR001873NHLBI NIH HHS T32 HL105323NIAID NIH HHS K23 AI163364
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

SepsisAdultAfrica South of the SaharaFemaleHIV InfectionsHumansMaleMiddle AgedProspective StudiesUgandaAfricaHIVimmune responsesproteomicssepsis

Identifiers

PMID39514831
PMCPMC11936143

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.