ArticleThe Journal of infectious diseases2025
2-[18F]F-p-Aminobenzoic Acid Specifically Detects Infective Endocarditis in Positron Emission Tomography.
Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Positron Emission Tomography Imaging of Bacterial Infections With an Enterobactin Analog to Monitor Treatment Efficacy With a Catechol Antibiotic.Angewandte Chemie (International ed. in English) · 2026Article
- Automated radiosynthesis of [Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2025Article
- Epidemiology, Pathogenesis, Clinical Features, and Management of Non-HACEK Gram-Negative Infective Endocarditis.Antibiotics (Basel, Switzerland) · 2025Review
- Multiple Imaging Modalities in the Diagnosis of Infective Endocarditis.Reviews in cardiovascular medicine · 2025Review
- Cellulosimicrobium cellulans endocarditis: a challenge for detection and treatment in interdisciplinary teams.Infection · 2025Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfective endocarditis (IE) is a life-threatening disease with high mortality, particularly when caused by Staphylococcus aureus (S aureus). Traditional diagnosis relies on clinical assessment, blood cultures, and imaging (eg, echocardiography) but lacks methods for direct bacterial detection on the endothelium. Positron emission tomography (PET)/computed tomography is emerging as valuable in unclear IE cases. This study evaluates 2-[18F]F-p-aminobenzoic acid (2-[18F]F-PABA), a bacteria-specific PET tracer, for detecting IE.
methodsIn vitro assays measured 2-[18F]F-PABA uptake by S aureus, distinguishing living bacteria from dead cells. A mouse model of IE provided proof-of-concept PET/magnetic resonance imaging (MRI) data for diagnosing IE. Additionally, a subcutaneous abscess model with larger bacterial vegetations was used to enhance imaging of bacterial uptake.
results2-[18F]F-PABA uptake by S aureus was confirmed in vitro, with accumulation limited to living bacteria and varying across strains. In vivo, 2-[18F]F-PABA PET/MRI successfully visualized IE in mice. In the subcutaneous abscess model, the tracer effectively localized S aureus vegetations, emphasizing its potential in detecting bacterial foci.
conclusionsThis study highlights the potential of 2-[18F]F-PABA PET imaging for direct visualization of IE. Future research may further investigate its diagnostic performance in larger models, aiming toward clinical application as a precise, pathogen-specific imaging tool for managing IE.
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