ArticleScience immunology2024
Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction.
Abstract read
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Article in Science immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Leucine-rich repeat kinase 2 (LRRK2): balancing cellular homeostasis and Parkinson's disease (PD) pathogenesis.Annals of medicine · 2026Review
- Gasdermin D in Neurodegenerative Diseases: Pathogenic Roles and Therapeutic Perspectives.Molecular neurobiology · 2026Review
- miR-369-3p Modulates LRRK2-Mediated Inflammation and Autophagy in RAW264.7 Macrophages.International journal of molecular sciences · 2026Article
- Paneth cells as orchestrators of epithelial barrier defense and emerging therapeutic targets in inflammatory bowel disease.Seminars in immunopathology · 2026Review
- Targeting cell death in Crohn's disease: from mechanisms to medicines.Cell death discovery · 2026Review
- Gut-Heart Axis in HFpEF: The Emerging Role of Microbiome-Driven Inflammation and Endothelial Dysfunction.Biomolecules · 2026Review
- Role of LRRK2 in physiological activities, diseases, and therapy.Chinese medical journal · 2026Review
- Mitophagy in inflammatory bowel disease: regulatory mechanisms and therapeutic potential.Frontiers in cell and developmental biology · 2026Review
- Shared genetic architecture of smoking dependence and Crohn's disease: A cross-trait analysis of GWAS summary statistics.Tobacco induced diseases · 2026Article
- Gene-environment interactions shape the host-microbial interface in inflammatory bowel disease.Nature immunology · 2025Review
- Inflammation and IL-4 regulate Parkinson's and Crohn's disease associated kinase LRRK2.EMBO reports · 2025Article
- Autophagy in inflammatory bowel disease: immunization, etiology, and therapeutic potential.Frontiers in immunology · 2025Review
- Guts for Self-Eating: Role of Autophagy in Gastrointestinal Health and Disease.Gastro hep advances · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors.
Shengxiang SunDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-5889-3292
Miki HodelDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0009-0008-5223-3822
Xiang WangDenali Therapeutics, South San Francisco, CA 94080, USA.ORCID 0000-0001-5134-1292
Javier De VicenteDenali Therapeutics, South San Francisco, CA 94080, USA.ORCID 0000-0003-2498-0843
Talin HarituniansF. Widjaja Foundation Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0002-9005-7750
Anketse DebebeDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount-Sinai, New York, NY 10029, USA.
Chen-Ting HungDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-0143-8445
Changqing MaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-6117-9505
Atika MaliqueDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0009-0007-1567-4154
Hoang N NguyenDenali Therapeutics, South San Francisco, CA 94080, USA.ORCID 0000-0001-6608-7581
Maayan AgamDenali Therapeutics, South San Francisco, CA 94080, USA.
Michael T MaloneyDenali Therapeutics, South San Francisco, CA 94080, USA.ORCID 0000-0002-1805-1477
Marisa S GooDenali Therapeutics, South San Francisco, CA 94080, USA.ORCID 0000-0002-1755-5649
Jillian H KlussDenali Therapeutics, South San Francisco, CA 94080, USA.
Richa MishraDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0009-0000-5430-557X
Jennifer FreinDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0009-0006-1177-0897
Amanda FosterDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Samuel BallentineDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-6339-548X
Uday PandeyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8674-7257
Justin KernDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Shaohong YangF. Widjaja Foundation Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Emebet MengeshaF. Widjaja Foundation Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0001-7830-1557
Iyshwarya BalasubramanianDepartment of Biological Sciences, Rutgers, State University of New Jersey, Newark, NJ 07102, USA.
Annie ArguelloDenali Therapeutics, South San Francisco, CA 94080, USA.ORCID 0000-0002-0313-0041
Anthony A EstradaDenali Therapeutics, South San Francisco, CA 94080, USA.
Nan GaoDepartment of Biological Sciences, Rutgers, State University of New Jersey, Newark, NJ 07102, USA.
Inga PeterDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount-Sinai, New York, NY 10029, USA.ORCID 0000-0002-5638-9137
Dermot P B McGovernF. Widjaja Foundation Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Anastasia G HenryDenali Therapeutics, South San Francisco, CA 94080, USA.ORCID 0000-0002-8124-5477
Thaddeus S StappenbeckDepartment of Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA.ORCID 0000-0002-6023-3901
Ta-Chiang LiuDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-2800-9360
Funding
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MThe Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI AMITABH CHAK · 2015 to 2026
$15.6MUtilizing the Phenomics of IBD to Enhance Gene DiscoveryU01DK062413 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Dermot Patrick McGovern · 2002 to 2026
$12.2MPaneth cell heterogeneity in infection and inflammationR01DK132885 · NIDDK · RUTGERS THE STATE UNIV OF NJ NEWARK · PI Nan Gao · 2022 to 2026
$2.4MMechanism of intestinal TET3-mediated DNA oxidation and transcriptional regulationR01DK139790 · NIDDK · RUTGERS THE STATE UNIV OF NJ NEWARK · PI Jean-Pierre Etchegaray, Nan Gao · 2024 to 2026
$2.1MDietary modulation of Paneth cellsR01DK136829 · NIDDK · WASHINGTON UNIVERSITY · PI Ta-Chiang Liu · 2023 to 2026
$2.1MResearch Supplements to Promote Diversity in Health-Related ResearchR01DK119198 · NIDDK · RUTGERS THE STATE UNIV OF NJ NEWARK · PI GAO, NAN, KIELA, PAWEL R · 2019 to 2023
$1.9MPaneth cell phenotype as a predictive biomarker for ulcerative colitisR01DK124274 · NIDDK · WASHINGTON UNIVERSITY · PI LIU, TA-CHIANG · 2020 to 2023
$1.5MCellular and molecular mechanisms of cigarette smoking-induced Paneth cell abnormalityR01DK125296 · NIDDK · WASHINGTON UNIVERSITY · PI LIU, TA-CHIANG · 2020 to 2023
$1.4MNIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK119198NIDDK NIH HHS R01 DK124274NIDDK NIH HHS R01 DK125296NIDDK NIH HHS R01 DK132885NIDDK NIH HHS R01 DK136829NIDDK NIH HHS R01 DK139790NIDDK NIH HHS U01 DK062413
Abstract
PubMed holds no abstract for this paper.
Indexed as
AutophagyCrohn DiseaseLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MacrophagesPaneth CellsAnimalsFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanLrrk2 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.