ArticlePloS one2024
Association of METS-IR index with Type 2 Diabetes: A cross-sectional analysis of national health and nutrition examination survey data from 2009 to 2018.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Metabolic score for insulin resistance and cancer mortality: Effect modification by hypertension in a nationwide cohort study.Medicine · 2026Article
- Article
- Association between different atherogenic and insulin resistance indices and infertility in polycystic ovary syndrome patients.PloS one · 2026Article
- Investigating the prediction potential of cholesterol, high-density lipoprotein, and glucose index surpasses TyG, AIP, and METS-IR for type 2 diabetes: a longitudinal cohort study.Frontiers in endocrinology · 2026Article
- Beyond HOMA-IR: Comparative Evaluation of Insulin Resistance and Anthropometric Indices Across Prediabetes and Type 2 Diabetes Mellitus in Metabolic Syndrome Patients.Life (Basel, Switzerland) · 2025Article
- Relationship Between Insulin Resistance Indicators and Type 2 Diabetes Mellitus in Romania.International journal of molecular sciences · 2025Article
- Association between the cholesterol, high-density lipoprotein, and glucose index and type 2 diabetes mellitus prevalence in US adults: A cross-sectional study based on National Health and Nutrition Examination Survey 2009-2018.The Journal of international medical research · 2025Article
- Nonlinear relationship between body fat percentage and NAFLD mediated by METS-IR: threshold effects and subgroup differences.Scientific reports · 2025Article
- The Metabolic Score for Insulin Resistance (METS-IR), a Predictor of Cardiovascular Events, Relates to Disease Activity in Patients with Rheumatoid Arthritis.Diagnostics (Basel, Switzerland) · 2025Article
- Association of metabolic score for insulin resistance with gestational diabetes mellitus: a multicenter cohort study.Frontiers in nutrition · 2025Article
- Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cardiovascular disease mortality in patients with type 2 diabetes mellitus and diabetic kidney disease.Frontiers in endocrinology · 2025Article
- Association between METS-IR and female infertility: a cross-sectional study of NHANES 2013-2018.Frontiers in nutrition · 2025Article
- Assessment of insulin resistance in different phases of bipolar disorder with the triglyceride glucose index, triglyceride glucose-body mass index, and metabolic score index for insulin resistance.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Article
- Relationship of METS-IR with cardiometabolic multimorbidity in China: a nationwide longitudinal cohort study.Frontiers in nutrition · 2025Article
- Cardiometabolic multimorbidity in relation to the metabolic score for insulin resistance and creatinine-to-cystatin C ratio in a middle-aged and aged population.Frontiers in endocrinology · 2025Article
- Non-linear association between metabolic score for insulin resistance and diabetes mellitus in normal-weight middle-aged and older Chinese adults: a multicenter retrospective cohort study.Frontiers in nutrition · 2025Article
- The relationship between cholesterol, high-density lipoprotein, and glucose index and hypertension: A study based on two national cohorts.Science progressArticle
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWith rising global diabetes prevalence, precise early identification and management of diabetes risk are critical research areas. The metabolic score for insulin resistance (METS-IR), a novel non-insulin-based tool, is gaining attention for quantifying insulin resistance using multiple metabolic parameters. Despite its potential in predicting diabetes and its precursors, evidence on its specific relationship with diabetes is limited, especially in large-scale population validation and mechanistic exploration.
objectiveThis study aims to analyze the association between METS-IR and type 2 diabetes (T2DM) in American adults.
methodsWe conducted a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) data from 2009 to 2018. Participants aged 20 years and above were included, excluding individuals with missing data on BMI, fasting blood glucose, high-density lipoprotein cholesterol glycated hemoglobin and diabetes status. Logistic regression analysis, subgroup analysis, and restricted cubic spline analysis were used to assess the association between METS-IR and T2DM, controlling for potential confounding factors.
resultsAfter adjusting for age, gender, race, education level, smoking status, drinking habits, depression, physical activity, hypertension, and hyperlipidemia, we found a positive association between METS-IR and the risk of T2DM. Specifically, each unit increase in METS-IR was associated with a 7% increase in the risk of T2DM (OR = 1.07, 95% CI: 1.06, 1.08). Subgroup analysis showed that the association between METS-IR and T2DM incidence was significantly positive in the highest quartile group, particularly among Mexican Americans over 40 years old and those diagnosed with depression, hypertension, or hyperlipidemia.
conclusionOur study revealed a significant positive association between METS-IR and the prevalence of T2DM, indicating that this relationship persists even after controlling for various confounding factors. Therefore, monitoring METS-IR may provide a valuable tool for the early identification of individuals at risk of glucose metabolism disorders. Further research should focus on the applicability of METS-IR in different populations and its potential impact on clinical practice.
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