Evidence map›Paper›PMID 39514514›Full record

SynthesisPloS one2024

Determinants of preterm prelabor rupture of fetal membrane among pregnant women in Ethiopia: A systematic review and meta-analysis.

Habtamu Geremew, Mohammed Ahmed Ali, Mulat Belay Simegn, Eyasu Bamlaku Golla, Alegntaw Abate, Smegnew Gichew Wondie, Hawi Kumbi, Mitku Mammo Taderegew, Werkneh Melkie Tilahun

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Habtamu GeremewCollege of Health Science, Oda Bultum University, Chiro, Ethiopia.ORCID 0000-0002-9027-9847
Mohammed Ahmed AliDepartment of Midwifery, College of Health Science, Oda Bultum University, Chiro, Ethiopia.
Mulat Belay SimegnDepartment of Public Health, College of Medicine and Health Science, Debre Markos University, Debre Markos, Ethiopia.
Eyasu Bamlaku GollaCollege of Health Science, Oda Bultum University, Chiro, Ethiopia.
Alegntaw AbateDepartment of Medical Laboratory Science, College of Health Science, Oda Bultum University, Chiro, Ethiopia.
Smegnew Gichew WondieDepartment of Human Nutrition, College of Medicine and Health Science, Mizan Tepi University, Mizan Aman, Ethiopia.
Hawi KumbiDepartment of Laboratory, Adama Hospital Medical College, Adama, Ethiopia.
Mitku Mammo TaderegewDepartment of Biomedical Sciences, College of Medicine and Health Sciences, Wolkite University, Wolkite, Ethiopia.
Werkneh Melkie TilahunDepartment of Public Health, College of Medicine and Health Science, Debre Markos University, Debre Markos, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEthiopia is one of the countries where persistently high neonatal and maternal mortalities are reported. Preterm prelabor rupture of membrane (PPROM) plays an important contribution to these high mortalities. However, there is a paucity of comprehensive evidence about the epidemiology of PPROM in Ethiopia. Therefore, this systematic review was conducted to assess the pooled prevalence and determinants of PPROM among pregnant women in Ethiopia.

methodsA systematic review and meta-analysis were conducted following the PRISMA guideline. Relevant literatures were searched on African Journals Online (AJOL), PubMed, Scopus, Epistemonikos, CINAHL, Cochrane Library and gray literature. All statistical analyses were performed using STATA 17 software. The random effect meta-analysis model was employed to summarize the pooled estimates. Heterogeneity between included studies was evaluated using I2 statistic. Egger's regression test and Begg's correlation test were employed to assess publication bias, in conjunction with funnel plot. Besides, the non-parametric trim-and-fill analysis, sensitivity analysis, subgroup analysis and meta-regression were also performed.

resultsA total of 13 original studies with 24,386 participants were considered in this systematic review. The pooled prevalence of PPROM was 6.58% (95% CI: 5.36, 7.79). Urinary tract infection (OR: 3.44; 95% CI: 1.81, 6.53), abnormal vaginal discharge (OR: 4.78; 95% CI: 2.85, 8.01), vaginal bleeding (OR: 2.04; 95% CI: 1.03, 4.06), history of PROM (OR: 4.64; 95% CI: 2.71, 7.95), history of abortion (OR: 3.06; 95% CI: 1.71, 5.46), malnutrition (OR: 5.24; 95% CI: 2.63, 10.44), anemia (OR: 3.97; 95% CI: 2.01, 7.85) and gestational diabetes (OR: 5.08; 95% CI: 1.93, 13.36) were significantly associated with PPROM.

conclusionThis meta-analysis found a high prevalence of PPROM in Ethiopia. Urinary tract infection, abnormal vaginal discharge, vaginal bleeding, history of PROM, history of abortion, malnutrition, anemia and gestational diabetes were risk factors for PPROM. Prevention and control of antenatal infections and malnutrition are highly recommended to reduce the magnitude of PPROM in Ethiopia. Additionally, healthcare providers should emphasize the identified risk factors. PROTOCOL REGISTRATION NUMBER: CRD42024536647.

Indexed as

Premature Rupture of Fetal MembranesEthiopiaFemaleHumansPregnancyPrevalenceRisk Factors

Identifiers

PMID39514514
PMCPMC11548779

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.