Evidence map›Paper›PMID 39514319›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Microbial metabolism disrupts cytokine activity to impact host immune response.

Eleanor K P Marshall, Catarina Nunes, Sophie Burbaud, Crystal M Vincent, Natalie O Munroe, Carolina J Simoes da Silva, Ashima Wadhawan, William H Pearson, Jasper Sangen, Lucas Boeck and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Frontiers in tuberculosis · 2025
    Review
  5. Microbial metabolism disrupts cytokine activity to impact host immune response.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eleanor K P MarshallCentre for Bacterial Resistance Biology, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0001-8877-821X
Catarina NunesCentre for Bacterial Resistance Biology, Imperial College London, London SW7 2AZ, United Kingdom.
Sophie BurbaudDepartment of Medicine, Molecular Immunity Unit, University of Cambridge, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Crystal M VincentCentre for Bacterial Resistance Biology, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0002-4812-4913
Natalie O MunroeCentre for Bacterial Resistance Biology, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0009-0005-8497-7437
Carolina J Simoes da SilvaCentre for Bacterial Resistance Biology, Imperial College London, London SW7 2AZ, United Kingdom.
Ashima WadhawanCentre for Bacterial Resistance Biology, Imperial College London, London SW7 2AZ, United Kingdom.
William H PearsonCentre for Bacterial Resistance Biology, Imperial College London, London SW7 2AZ, United Kingdom.
Jasper SangenDepartment of Medicine, Molecular Immunity Unit, University of Cambridge, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Lucas BoeckDepartment of Biomedicine, University of Basel, Basel 4031, Switzerland.
R Andres FlotoDepartment of Medicine, Molecular Immunity Unit, University of Cambridge, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Marc S DionneCentre for Bacterial Resistance Biology, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0002-8283-1750

Funding

Leverhulme Trust RPG-2022-337Medical Research Council MR/P028225/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/W001004/1UKRI | Medical Research Council (MRC) 2367572UKRI | Medical Research Council (MRC) MR/R00997X/1Wellcome TrustWellcome Trust (WT) 107032AIAWellcome Trust (WT) 207467/Z/17/ZWellcome Trust (WT) 226602/Z/22/Z
6 · The paper itself

Abstract

Host-pathogen interactions are shaped by the metabolic status of both the host and pathogen. The host must regulate metabolism to fuel the immune response, while the pathogen must extract metabolic resources from the host to enable its own survival. In this study, we focus on the metabolic interactions of

Indexed as

CytokinesDrosophila melanogasterHost-Pathogen InteractionsMycobacterium abscessusAmino Acid Transport SystemsAnimalsAsparagineBacterial ProteinsImmunity, InnateMycobacterium Infections, NontuberculousSignal TransductionAmino Acid Transport SystemsAsparagineBacterial ProteinsCytokinesDrosophila melanogasterinfectioninnate immunitymetabolismMycobacterium abscessus

Identifiers

PMID39514319
PMCPMC11573640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.